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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Petrache, Horia I. Tristram-Nagle, Stephanie Harries, Daniel Kucerka, Norbert Nagle, John F. Parsegian, V. Adrian |
| Description | Country affiliation: United States Author Affiliation: Petrache HI ( Laboratory of Physical and Structural Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-0924, USA. petrachh@mail.nih.gov) |
| Abstract | Critical to biological processes such as membrane fusion and secretion, ion-lipid interactions at the membrane-water interface still raise many unanswered questions. Using reconstituted phosphatidylcholine membranes, we confirm here that multilamellar vesicles swell in salt solutions, a direct indication that salt modifies the interactions between neighboring membranes. By varying sample histories, and by comparing with data from ion carrier-containing bilayers, we eliminate the possibility that swelling is an equilibration artifact. Although both attractive and repulsive forces could be modified by salt, we show experimentally that swelling is driven primarily by weakening of the van der Waals attraction. To isolate the effect of salt on van der Waals interactions, we focus on high salt concentrations at which any possible electrostatic interactions are screened. By analysis of X-ray diffraction data, we show that salt does not alter membrane structure or bending rigidity, eliminating the possibility that repulsive fluctuation forces change with salt. By measuring changes in interbilayer separation with applied osmotic stress, we have determined, using the standard paradigm for bilayer interactions, that 1 M concentrations of KBr or KCl decrease the van der Waals strength by 50%. By weakening van der Waals attractions, salt increases energy barriers to membrane contact, possibly affecting cellular communication and biological signaling. |
| File Format | HTM / HTML |
| ISSN | 00222275 |
| e-ISSN | 15397262 |
| Journal | The Journal of Lipid Research |
| Issue Number | 2 |
| Volume Number | 47 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology |
| Publisher Date | 2006-02-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Biochemistry Anions Chemistry Phospholipids Algorithms Bromides Chlorides Dimyristoylphosphatidylcholine Lipid Bilayers Liposomes Models, Chemical Osmotic Pressure Phosphatidylcholines Static Electricity Thermodynamics X-ray Diffraction Research Support, N.i.h., Extramural Research Support, U.s. Gov't, Non-p.h.s. |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Endocrinology |
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