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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Minehira, Kaori Young, Stephen G. Villanueva, Claudio J. Yetukuri, Laxman Oresic, Matej Hellerstein, Mark K. Farese, Robert V. Horton, Jay D. Preitner, Frederic Thorens, Bernard Tappy, Luc |
| Description | Country affiliation: United States Author Affiliation: Minehira K ( Gladstone Institute of Cardiovascular Disease, University of California-San Francisco, CA 94158, USA. kaori.minehira@unil.ch) |
| Abstract | The liver secretes triglyceride-rich VLDLs, and the triglycerides in these particles are taken up by peripheral tissues, mainly heart, skeletal muscle, and adipose tissue. Blocking hepatic VLDL secretion interferes with the delivery of liver-derived triglycerides to peripheral tissues and results in an accumulation of triglycerides in the liver. However, it is unclear how interfering with hepatic triglyceride secretion affects adiposity, muscle triglyceride stores, and insulin sensitivity. To explore these issues, we examined mice that cannot secrete VLDL [due to the absence of microsomal triglyceride transfer protein (Mttp) in the liver]. These mice exhibit markedly reduced levels of apolipoprotein B-100 in the plasma, along with reduced levels of triglycerides in the plasma. Despite the low plasma triglyceride levels, triglyceride levels in skeletal muscle were unaffected. Adiposity and adipose tissue triglyceride synthesis rates were also normal, and body weight curves were unaffected. Even though the blockade of VLDL secretion caused hepatic steatosis accompanied by increased ceramides and diacylglycerols in the liver, the mice exhibited normal glucose tolerance and were sensitive to insulin at the whole-body level, as judged by hyperinsulinemic euglycemic clamp studies. Normal hepatic glucose production and insulin signaling were also maintained in the fatty liver induced by Mttp deletion. Thus, blocking VLDL secretion causes hepatic steatosis without insulin resistance, and there is little effect on muscle triglyceride stores or adiposity. |
| File Format | HTM / HTML |
| ISSN | 00222275 |
| e-ISSN | 15397262 |
| DOI | 10.1194/jlr.M800248-JLR200 |
| Journal | The Journal of Lipid Research |
| Issue Number | 9 |
| Volume Number | 49 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology |
| Publisher Date | 2008-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Biochemistry Fatty Liver Etiology Insulin Resistance Lipid Metabolism Lipoproteins, Vldl Secretion Adipose Tissue Metabolism Animals Carrier Proteins Genetics Lipids Blood Mice Muscle, Skeletal Chemistry Triglycerides Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Endocrinology |
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