NDLI: Western diet changes cardiac acyl-CoA composition in obese rats: a potential role for hepatic lipogenesis.

Please wait, while we are loading the content...

PPARdelta is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction.

Effects of human follicular fluid and high-density lipoproteins on early spermatozoa hyperactivation and cholesterol efflux.

New insights on the protein-ligand interaction differences between the two primary cellular retinol carriers.

VLDL lipolysis products increase VLDL fluidity and convert apolipoprotein E4 into a more expanded conformation

Identification of atypical ether-linked glycerophospholipid species in macrophages by mass spectrometry.

Participation of ATP7A in macrophage mediated oxidation of LDL.

Monitoring of fatty aldehyde dehydrogenase by formation of pyrenedecanoic acid from pyrenedecanal.

Novel acyl-coenzyme A:monoacylglycerol acyltransferase plays an important role in hepatic triacylglycerol secretion.

Bile alcohols function as the ligands of membrane-type bile acid-activated G protein-coupled receptor.

FAT/CD36 is localized in sarcolemma and in vesicle-like structures in subsarcolemma regions but not in mitochondria.

Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia

Rapid and selective detection of fatty acylated proteins using omega-alkynyl-fatty acids and click chemistry.

Effects of FoxO4 overexpression on cholesterol biosynthesis, triacylglycerol accumulation, and glucose uptake.

Strong induction of PCSK9 gene expression through HNF1α and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters

Targeted PPAR{gamma} deficiency in alveolar macrophages disrupts surfactant catabolism.

Dietary docosahexaenoic acid supplementation alters select physiological endocannabinoid-system metabolites in brain and plasma.

n-3 PUFA improves fatty acid composition, prevents palmitate-induced apoptosis, and differentially modifies B cell cytokine secretion in vitro and ex vivo.

A genome-wide linkage scan identifies multiple quantitative trait loci for HDL-cholesterol levels in families with premature CAD and MI.

A new HDL mimetic peptide that stimulates cellular cholesterol efflux with high efficiency greatly reduces atherosclerosis in mice.

The relative atherogenicity of VLDL and LDL is dependent on the topographic site.

Western diet changes cardiac acyl-CoA composition in obese rats: a potential role for hepatic lipogenesis.

Rapid quantification of conjugated and unconjugated bile acids and C27 precursors in dried blood spots and small volumes of serum.

Functional analysis of the missense APOC3 mutation Ala23Thr associated with human hypotriglyceridemia.

Enzymatic assessment of cholesterol on electrophoresis gels for estimating HDL size distribution and plasma concentrations of HDL subclasses.

Regulating survival and development in the retina: key roles for simple sphingolipids

TNF-alpha decreases ABCA1 expression and attenuates HDL cholesterol efflux in the human intestinal cell line Caco-2.

Reversibility of renal injury with cholesterol lowering in hyperlipidemic diabetic mice.

2D-NMR reveals different populations of exposed lysine residues in the apoB-100 protein of electronegative and electropositive fractions of LDL particles.

Selective desorption/ionization of sulfatides by MALDI-MS facilitated using 9-aminoacridine as matrix.

MicroRNA-370 controls the expression of microRNA-122 and Cpt1alpha and affects lipid metabolism.

Phosphoenolpyruvate carboxykinase (Pck1) helps regulate the triglyceride/fatty acid cycle and development of insulin resistance in mice.

A role of apolipoprotein D in triglyceride metabolism.

Chronic social defeat stress disrupts regulation of lipid synthesis.

Novel myelin penta- and hexa-acetyl-galactosyl-ceramides: structural characterization and immunoreactivity in cerebrospinal fluid.

Cholesterol loading in macrophages stimulates formation of ER-derived vesicles with elevated ACAT1 activity.

HNF1α and SREBP2 are important regulators of NPC1L1 in human liver

Year: 2010 Volume: 51 Issue: 5

Year: 2010 Volume: 51 Issue: 4

Year: 2010 Volume: 51 Issue: 3

Year: 2010 Volume: 51 Issue: 2

Year: 2010 Volume: 51 Issue: 1

Year: 2009 Volume: 50

Year: 2008 Volume: 49

Year: 2007 Volume: 48

Year: 2006 Volume: 47

Year: 2005 Volume: 46

Year: 2004 Volume: 45

Year: 2003 Volume: 44

Year: 2002 Volume: 43

Year: 2001 Volume: 42

Year: 2000 Volume: 41

Year: 1998 Volume: 39

Year: 1990 Volume: 31

Year: 1981 Volume: 22

Western diet changes cardiac acyl-CoA composition in obese rats: a potential role for hepatic lipogenesis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Harmancey, Romain Wilson, Christopher R. Wright, Nathan R. Taegtmeyer, Heinrich
Description	Country affiliation: United States Author Affiliation: Harmancey R ( Department of Internal Medicine, Division of Cardiology, University of Texas Medical School at Houston, TX 77030, USA.)
Abstract	The 'lipotoxic footprint' of cardiac maladaptation in diet-induced obesity is poorly defined. We investigated how manipulation of dietary lipid and carbohydrate influenced potential lipotoxic species in the failing heart. In Wistar rats, contractile dysfunction develops at 48 weeks on a high-fat/high-carbohydrate 'Western' diet, but not on low-fat/high-carbohydrate or high-fat diets. Cardiac content of the lipotoxic candidates--diacylglycerol, ceramide, lipid peroxide, and long-chain acyl-CoA species--was measured at different time points by high-performance liquid chromatography and biochemical assays, as was lipogenic capacity in the heart and liver by qRT-PCR and radiometric assays. Changes in membranes fluidity were also monitored using fluorescence polarization. We report that Western feeding induced a 40% decrease in myocardial palmitoleoyl-CoA content and a similar decrease in the unsaturated-to-saturated fatty acid ratio. These changes were associated with impaired cardiac mitochondrial membrane fluidity. At the same time, hepatic lipogenic capacity was increased in animals fed Western diet (+270% fatty acid elongase activity compared with high-fat diet), while fatty acid desaturase activity decreased over time. Our findings suggest that dysregulation of lipogenesis is a significant component of heart failure in diet-induced obesity.
File Format	HTM / HTML
ISSN	00222275
e-ISSN	15397262
DOI	10.1194/jlr.M001230
Journal	The Journal of Lipid Research
Issue Number	6
Volume Number	51
Language	English
Publisher	American Society for Biochemistry and Molecular Biology
Publisher Date	2010-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Biochemistry Acyl Coenzyme A Metabolism Diet Lipogenesis Liver Myocardium Obesity Adaptation, Physiological Drug Effects Animals Cell Membrane Adverse Effects Dietary Carbohydrates Pharmacology Dietary Fats Fatty Acids Biosynthesis Blood Chemistry Gene Expression Regulation, Enzymologic Heart Physiopathology Lipid Metabolism Enzymology Muscle Contraction Pathology Etiology Stearoyl-coa Desaturase Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Endocrinology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Compartmentalization of stearoyl-coenzyme A desaturase 1 activity in HepG2 cells.

Hepatic lipid composition and stearoyl-coenzyme A desaturase 1 mRNA expression can be estimated from plasma VLDL fatty acid ratios.

Dietary polyunsaturated fatty acids (C18:2 ω6 and C18:3 ω3) do not suppress hepatic lipogenesis

Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol

Stearoyl-CoA desaturase and its relation to high-carbohydrate diets and obesity.

Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity.

Loss of stearoyl-CoA desaturase 1 rescues cardiac function in obese leptin-deficient mice.

Lipidomics of hepatic lipogenesis inhibition by omega 3 fatty acids.

Stearoyl-CoA Desaturase: A Control Enzme in Hepatic Lipogenesis

Western diet changes cardiac acyl-CoA composition in obese rats: a potential role for hepatic lipogenesis.

Similar Documents

Compartmentalization of stearoyl-coenzyme A desaturase 1 activity in HepG2 cells.

Hepatic lipid composition and stearoyl-coenzyme A desaturase 1 mRNA expression can be estimated from plasma VLDL fatty acid ratios.

Dietary polyunsaturated fatty acids (C18:2 ω6 and C18:3 ω3) do not suppress hepatic lipogenesis

Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol

Stearoyl-CoA desaturase and its relation to high-carbohydrate diets and obesity.

Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity.

Loss of stearoyl-CoA desaturase 1 rescues cardiac function in obese leptin-deficient mice.

Lipidomics of hepatic lipogenesis inhibition by omega 3 fatty acids.

Stearoyl-CoA Desaturase: A Control Enzme in Hepatic Lipogenesis

Western diet changes cardiac acyl-CoA composition in obese rats: a potential role for hepatic lipogenesis.