NDLI: Influence of development, HIV infection, and antiretroviral therapies on the gene expression profiles of ABC transporters in human lymphocytes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Giraud, Carole Manceau, Sandra Declèves, Xavier Goffinet, François Morini, Jean-Pierre Chappuy, Hélène Batteux, Frédéric Chouzenoux, Sandrine Yousif, Salah Scherrmann, Jean-Michel Blanche, Stéphane Tréluyer, Jean-Marc
Description	Country affiliation: France Author Affiliation: Giraud C ( Centre de Recherche Clinique Paris Descartes, Groupe Hospitalier Cochin-Saint-Vincent-de-Paul, Assistance Publique-Hôpitaux de Paris, Site Hôpital Tarnier, 75006 Paris, France. carole.giraud@cch.aphp.fr)
Abstract	The efficacy of drugs acting on lymphocytes like anticancer, immunosuppressive, and antiretroviral drugs depends on their intracellular concentrations, which could be modulated by membrane efflux pumps belonging to the ABC transporter superfamily. The gene expression profiles of 6 main ABC transporters (MDR1, MRP1, MRP3, MRP4, MRP5, and BCRP) were established in lymphocytes from birth to adulthood using blood samples from 57 children and 15 adults (34 and 5 HIV-infected, respectively). Gene expression levels were quantified by quantitative RT-PCR. In adults, the MRP1 gene had the highest expression, followed by the MRP5 gene. BCRP and MRP4 genes were significantly higher expressed at birth than after 1 month of life. Neither HIV infection nor antiretroviral therapies modulated the gene expression profiles of ABC transporters. In conclusion, drugs that are substrates of BCRP and MRP4, like zidovudine, may have an altered efficacy in newborns.
File Format	HTM / HTML
ISSN	00912700
Issue Number	2
Volume Number	50
e-ISSN	15524604
Journal	The Journal of Clinical Pharmacology
Language	English
Publisher	Wiley
Publisher Date	2010-02-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Atp-binding Cassette Transporters Genetics Anti-hiv Agents Pharmacology Hiv Infections Lymphocytes Metabolism Blood Adolescent Adult Age Factors Therapeutic Use Child Child, Preschool Gene Expression Profiling Drug Therapy Humans Infant Infant, Newborn Zidovudine Journal Article Multicenter Study Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical)

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