NDLI: Atenolol pharmacokinetics and excretion in breast milk during the first 6 to 8 months postpartum.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Eyal, Sara Kim, Joong D. Anderson, Gail D. Buchanan, Megan L. Brateng, Debra A. Carr, Darcy Woodrum, David E. Easterling, Thomas R. Hebert, Mary F.
Description	Country affiliation: United States Author Affiliation: Eyal S ( University of Washington Department of Pharmacy, Seattle, WA 98195-7630, USA.)
Abstract	The objectives were to evaluate the time course for atenolol pharmacokinetics in lactating women postpartum and to quantify atenolol plasma concentrations in the women's 3- to 4-month-old nursing infants. Data were collected during 1 dosing interval from lactating women treated with atenolol for therapeutic reasons, at 2 to 4 weeks (n = 32), 3 to 4 months (n = 22), and 6 to 8 months (n = 17) postpartum. A single blood sample was collected from 15 nursing infants (3-4 months of age) of the mothers participating in the study. At 2 to 4 weeks, 3 to 4 months, and 6 to 8 months postpartum, atenolol infant doses, relative to the mother's weight-adjusted dose, were 14.6% ± 7.6%, 8.3% ± 5.2% and 5.9% ± 2.9%, respectively. Over this time, maternal atenolol pharmacokinetics did not change to a clinically significant extent. Atenolol concentrations were below assay quantification limits (<10 ng/mL) in the plasma of all 3- to 4-month-old nursing infants studied. These findings support the careful use of atenolol during breastfeeding, because in the vast majority of healthy, term infants, atenolol concentrations will be too low to be clinically relevant. Premature infants and those with kidney disease require further study. Infant exposure depends on maternal dose and decreases during the first 6 to 8 months postpartum.
File Format	HTM / HTML
ISSN	00912700
e-ISSN	15524604
DOI	10.1177/0091270009358708
Journal	The Journal of Clinical Pharmacology
Issue Number	11
Volume Number	50
Language	English
Publisher	Wiley
Publisher Date	2010-11-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Pharmacology Antihypertensive Agents Pharmacokinetics Atenolol Milk, Human Chemistry Administration & Dosage Dose-response Relationship, Drug Infant Lactation Postpartum Period Pregnancy Time Factors Research Support, N.i.h., Extramural Research Support, U.s. Gov't, P.h.s.
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical)

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