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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Uotani, Takahiro Sugimoto, Mitsushige Nishino, Masafumi Ichikawa, Hitomi Sahara, Shu Yamade, Mihoko Iwaizumi, Moriya Yamada, Takanori Osawa, Satoshi Sugimoto, Ken Umemura, Kazuo Watanabe, Hiroshi Miyajima, Hiroaki Furuta, Takahisa |
| Description | Country affiliation: Japan Author Affiliation: Uotani T ( First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.) |
| Abstract | Anti-platelet drug-induced gastric mucosal injury correlates with intragastric pH. Our aim was to investigate prophylaxis effects of famotidine, one of the representative histamine-2 receptor antagonists (H2RA), on gastric mucosal injury induced by dual therapy with low-dose aspirin and clopidogrel in relation to Helicobacter pylori (H. pylori) infection and CYP2C19 genotypes. This study was conducted for 20 healthy Japanese volunteers (10 H. pylori-positive and 10-negative subjects) with 100 mg aspirin plus 75 mg clopidogrel (AC) once-daily dosing and AC plus 20 mg famotidine twice-daily dosing (ACH). Mucosal injury was endoscopically assessed on day 3 and 7 and 24-hour intragastric pH and antiplatelet-function test was performed on day 7. Median pH in ACH was similar between CYP2C19 extensive metabolizer (EM) and intermediate metabolizer (IM)/poor metabolizer (PM) and was significantly higher in H. pylori-positive than negative subjects (P < .05). Mucosal injury with ACH significantly decreased in both day 3 and 7 compared with AC, irrespective with H. pylori and CYP2C19 genotypes (P < .05). Although antiplatelet effect of clopidogrel in EM was significantly higher than that in IM/PM, the additional famotidine did not affect the effect. Anti-platelet drug-induced gastric injury was alleviated by famotidine without attenuation of anti-platelet functions irrespective of H. pylori and CYP2C19 genotypes. |
| File Format | HTM / HTML |
| ISSN | 00912700 |
| Issue Number | 8 |
| Volume Number | 54 |
| e-ISSN | 15524604 |
| Journal | The Journal of Clinical Pharmacology |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2014-08-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Anti-ulcer Agents Administration & Dosage Aspirin Adverse Effects Famotidine Gastric Mucosa Drug Effects Histamine H2 Antagonists Platelet Aggregation Inhibitors Ticlopidine Analogs & Derivatives Adult Asian Continental Ancestry Group Genetics Cytochrome P-450 Cyp2c19 Drug Therapy, Combination Female Gastric Acidity Determination Pathology Genotype Helicobacter Infections Drug Therapy Helicobacter Pylori Humans Hydrogen-ion Concentration Male Platelet Aggregation Young Adult Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmacology (medical) |
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