NDLI: Papillary lesions of the breast: outcomes of 156 patients managed without excisional biopsy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wyss, Paloma Varga, Zsuzsanna Rössle, Matthias Rageth, Christoph J.
Description	Country affiliation: Switzerland Author Affiliation: Wyss P ( Breast Center, Zürich, Switzerland.)
Abstract	Papillomas of the breast are benign epithelial neoplasms. Because of the low, but continued potential for malignancy, the treatment options after initial diagnosis remain controversial. The aim of this study was to analyze the clinical course of patients with papilloma who were managed by active surveillance following initial diagnosis by core needle biopsy or vacuum-assisted biopsy. This retrospective study analyzed 174 patients with 180 papillomas that were diagnosed by core needle biopsy (113 cases) or vacuum-assisted biopsy (67 cases) at the Breast Center Seefeld Zurich between February 2002 and May 2011. We excluded 24 cases that underwent excisional biopsy for removal of the lesion. Over a mean follow-up of 3.5 years, 13 further events occurred in 156 cases (8%). These events included two cases of ductal carcinoma in situ (one after 4 and one after 6 years), one case of atypical ductal hyperplasia, one radial scar, eight cases of papilloma, and one case of flat epithelial atypia. No invasive carcinomas occurred during the follow-up period. Conservative management of 156 papillary lesions with removal by vacuum-assisted biopsy and surveillance was not associated with invasive cancer over a median follow-up of 3.5 years. Therefore, this approach seems to be a safe option for the clinical management of papillary lesions.
File Format	HTM / HTML
ISSN	1075122X
Issue Number	4
Volume Number	20
e-ISSN	15244741
Journal	The Breast Journal
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2014-07-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Obstetrics Discipline Gynecology Discipline Oncology Biopsy Methods Breast Neoplasms Pathology Carcinoma, Papillary Adult Aged Aged, 80 And Over Biopsy, Large-core Needle Mortality Carcinoma, Intraductal, Noninfiltrating Female Follow-up Studies Humans Hyperplasia Kaplan-meier Estimate Mammary Glands, Human Middle Aged Retrospective Studies Young Adult Journal Article
Content Type	Text
Resource Type	Article
Subject	Internal Medicine Surgery Oncology

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