NDLI: Roux-en-Y gastric bypass ameliorates polycystic ovary syndrome and dramatically improves conception rates: a 9-year analysis.

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Roux-en-Y gastric bypass ameliorates polycystic ovary syndrome and dramatically improves conception rates: a 9-year analysis.

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Year: 2012 Volume: 8 Issue: 3

Year: 2012 Volume: 8 Issue: 2

Year: 2012 Volume: 8 Issue: 1

Roux-en-Y gastric bypass ameliorates polycystic ovary syndrome and dramatically improves conception rates: a 9-year analysis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jamal, Mohammad Gunay, Yusuf Capper, Alyssa Eid, Anas Heitshusen, Debi Samuel, Isaac
Description	Country affiliation: United States Author Affiliation: Jamal M ( Department of Surgery, University of Iowa, Carver College of Medicine, Iowa City, Iowa, USA.)
Abstract	BACKGROUND: Polycystic ovary syndrome (PCOS) is a common cause of infertility, especially in the morbidly obese. We evaluated the long-term effects of Roux-en-Y gastric bypass on PCOS and infertility. METHODS: A total of 566 morbidly obese women underwent Roux-en-Y gastric bypass from 2000 to 2009. A total of 31 patients (5.5%) had a history of PCOS. Of the 31 patients, 6 were postmenopausal and 5 lost to follow-up and were excluded. Telephone interviews were conducted with the 20 eligible patients. RESULTS: The mean age and body mass index was 32 ± 5.8 years (range 22-42) and 52.8 ± 9.08 kg/m(2) (range 37-76) before surgery. All 20 patients had ≥ 2 of 3 diagnostic criteria for PCOS, including clinical or biochemical evidence of hyperandrogenism, anovulation, or polycystic ovaries. Of these, 85% had oligomenorrhea, 70% had hirsutism, and 45% had type 2 diabetes mellitus with medication. Before surgery, 8 patients conceived with or without hormonal treatment, 2 did not desire pregnancy, and 10 did not conceive. The mean follow-up was 46.7 months. After surgical weight loss, menstruation was corrected in 82%, hirsutism had resolved in 29%, and 77.8% of those with diabetes had complete remission. Of the 10 patients who did not conceive before surgery, 4 no longer desired pregnancy, and the remaining 6 patients had become pregnant within 3 years of surgery-5 without any hormonal treatment and 1 with in utero insemination. CONCLUSION: Surgical weight loss after Roux-en-Y gastric bypass achieves excellent amelioration of PCOS manifestations and the postoperative conception rate in infertile PCOS subjects desiring pregnancy was 100%.
File Format	HTM / HTML
ISSN	15507289
Issue Number	4
Volume Number	8
e-ISSN	18787533
Journal	Surgery for Obesity and Related Diseases
Language	English
Publisher	Elsevier
Publisher Date	2012-07-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Metabolism Discipline General Surgery Gastric Bypass Infertility, Female Surgery Obesity, Morbid Polycystic Ovary Syndrome Adult Body Mass Index Female Humans Complications Etiology Preconception Care Methods Pregnancy Pregnancy Rate Retrospective Studies Treatment Outcome Weight Loss Young Adult Journal Article
Content Type	Text
Resource Type	Article
Subject	Surgery

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Roux-en-Y gastric bypass ameliorates polycystic ovary syndrome and dramatically improves conception rates: a 9-year analysis.

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Roux-en-Y gastric bypass ameliorates polycystic ovary syndrome and dramatically improves conception rates: a 9-year analysis.