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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lee, J. C. Shin, I. S. Ahn, T. H. Kim, K. H. Moon, C. Kim, S. H. Shin, D. H. Park, S. C. Kim, Y. B. Kim, J. C. |
| Description | Country affiliation: South Korea Author Affiliation: Lee JC ( Animal Medical Center, College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, South Korea.) |
| Abstract | This study investigated the potential adverse effects of 1,3-dichloro-2-propanol (1,3-DCP) on pregnant dams and the embryo-fetal development after maternal exposure on gestational days (GD) 6 through 19 in Sprague-Dawley rats. The test chemical was administered to pregnant rats by gavage at dose levels of 0, 10, 30, and 90mg/kg per day (n=10 for each group). All dams underwent Caesarean sections on GD 20, and their fetuses were examined for morphological abnormalities. Maternal toxicity was noted at 90mg/kg/day. Manifestations of toxicity included clinical signs of illness, lower body weight gain, decreased food intake, and increases in the weight of the adrenal glands and the liver. Developmental toxic effects including decreases in fetal body weight and increases in visceral and skeletal variations also occurred at the highest dose. At 30mg/kg, only a minimal maternal toxicity, including a decrease in maternal food intake and an increase in the liver weight, was observed. No adverse maternal or developmental effects were observed at 10mg/kg/day. These results revealed that a 14-day repeated oral dose of 1,3-DCP was minimally embryotoxic but not teratogenic at a maternal toxic dose (90mg/kg/day), and was not embryotoxic at a minimally maternal toxic dose (30mg/kg/day) in rats. Because the developmental toxicity of 1,3-DCP was observed only in the presence of maternal toxicity, it is concluded that the developmental findings observed in the present study are secondary effects to maternal toxicity. Under these experimental conditions, the no-observed-adverse-effect level of 1,3-DCP is considered to be 10mg/kg/day for dams and 30mg/kg/day for embryo-fetal development. |
| File Format | HTM / HTML |
| ISSN | 02732300 |
| Issue Number | 1 |
| Volume Number | 53 |
| e-ISSN | 10960295 |
| Journal | Regulatory Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2009-02-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Fetal Development Drug Effects Maternal Exposure Mutagens Toxicity Alpha-chlorohydrin Analogs & Derivatives Administration, Oral Animals Dose-response Relationship, Drug Eating Female Fetal Weight Male Administration & Dosage No-observed-adverse-effect Level Organ Size Pregnancy Rats Rats, Sprague-dawley Weight Gain Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology |
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