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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yang, Young-Su Kwon, Jung-Taek Shim, Ilseob Kim, Hyun-Mi Kim, Pilje Kim, Jong-Choon Lee, Kyuhong |
| Description | Author Affiliation: Yang YS ( Jeonbuk Department of Inhalation Research, Korea Institute of Toxicology, Jeonbuk 580-185, Republic of Korea.); Kwon JT ( Environmental Health Research Department, National Institute of Environmental Research, Incheon 404-708, Republic of Korea.); Shim I ( Environmental Health Research Department, National Institute of Environmental Research, Incheon 404-708, Republic of Korea.); Kim HM ( Environmental Health Research Department, National Institute of Environmental Research, Incheon 404-708, Republic of Korea.); Kim P ( Environmental Health Research Department, National Institute of Environmental Research, Incheon 404-708, Republic of Korea.); Kim JC ( College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Republic of Korea. Electronic address: toxkim@jnu.ac.kr.); Lee K ( Jeonbuk Department of Inhalation Research, Korea Institute of Toxicology, Jeonbuk 580-185, Republic of Korea. Electronic address: khlee@kitox.re.kr.) |
| Abstract | The present study was conducted to investigate the potential subchronic toxicity of triclosan (TCS) in rats following 28 days of exposure by repeated inhalation. Four groups of six rats of each sex were exposed to TCS-containing aerosols by nose-only inhalation of 0, 0.04, 0.13, or 0.40 mg/L for 6 h/day, 5 days/week over a 28-day period. During the study period, clinical signs, mortality, body weight, food consumption, ophthalmoscopy, hematology, serum biochemistry, gross pathology, organ weights, and histopathology were examined. At 0.40 mg/L, rats of both sexes exhibited an increase in the incidence of postdosing salivation and a decrease in body weight. Histopathological alterations were found in the nasal septum and larynx. There were no treatment-related effects in rats of either sex at ⩽0.13 mg/L. Under the present experimental conditions, the target organs in rats were determined to be the nasal cavity and larynx. The no-observed-adverse-effect concentration in rats was determined to be 0.13 mg/L. |
| File Format | HTM / HTML |
| ISSN | 02732300 |
| Issue Number | 2 |
| Volume Number | 71 |
| e-ISSN | 10960295 |
| Journal | Regulatory Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Aerosols Administration & Dosage Toxicity Inhalation Exposure Adverse Effects Triclosan Administration, Inhalation Animals Body Weight Drug Effects Drug Evaluation, Preclinical Methods Female Male Rats Rats, Sprague-dawley Time Factors Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology |
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