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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Safford, B. Api, A. M. Barratt, C. Comiskey, D. Ellis, G. McNamara, C. O'Mahony, C. Robison, S. Rose, J. Smith, B. Tozer, S. |
| Description | Country affiliation: United kingdom Author Affiliation: Safford B ( B-Safe Toxicology Consulting, 31 Hayway, Rushden, Northants, NN10 6AG, United Kingdom.); Api AM ( Research Institute for Fragrance Materials, 50 Tice Boulevard, Woodcliff Lake, NJ 07677, United States of America. Electronic address: amapi@rifm.org.); Barratt C ( Unilever, Safety and Environmental Assurance Centre, Colworth Park, Sharnbrook, Beds, MK44 1LQ, United Kingdom.); Comiskey D ( Creme Global Ltd, The Tower, Trinity Enterprise Centre, Grand Canal Quay, Dublin 2, Ireland.); Ellis G ( Givaudan International S.A., 5 chemin de la parfumerie, CH1214, Vernier, Switzerland.); McNamara C ( Creme Global Ltd, The Tower, Trinity Enterprise Centre, Grand Canal Quay, Dublin 2, Ireland.); O'Mahony C ( Creme Global Ltd, The Tower, Trinity Enterprise Centre, Grand Canal Quay, Dublin 2, Ireland.); Robison S ( SH Robison Consulting, LLC, P.O. Box 688, Milford, OH 45150, United States.); Rose J ( The Procter and Gamble Company, Sharon Woods Innovation Center, 11530 Reed Hartman Hwy, Cincinnati, OH 45241, United States.); Smith B ( Firmenich Inc., P.O. Box 5880, Princeton, NJ 08543, United States.); Tozer S ( Procter&Gamble, Surrey, TW20 9NW, United Kingdom.) |
| Abstract | As part of a joint project between the Research Institute for Fragrance Materials (RIFM) and Creme Global, a Monte Carlo model (here named the Creme RIFM model) has been developed to estimate consumer exposure to ingredients in personal care products. Details of the model produced in Phase 1 of the project have already been published. Further data on habits and practises have been collected which enable the model to estimate consumer exposure from dermal, oral and inhalation routes for 25 product types. . In addition, more accurate concentration data have been obtained which allow levels of fragrance ingredients in these product types to be modelled. Described is the use of this expanded model to estimate aggregate systemic exposure for eight fragrance ingredients. Results are shown for simulated systemic exposure (expressed as µg/kg bw/day) for each fragrance ingredient in each product type, along with simulated aggregate exposure. Highest fragrance exposure generally occurred from use of body lotions, body sprays and hydroalcoholic products. For the fragrances investigated, aggregate exposure calculated using this model was 11.5-25 fold lower than that calculated using deterministic methodology. The Creme RIFM model offers a very comprehensive and powerful tool for estimating aggregate exposure to fragrance ingredients. |
| File Format | HTM / HTML |
| ISSN | 02732300 |
| Journal | Regulatory Toxicology and Pharmacology |
| Volume Number | 86 |
| e-ISSN | 10960295 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2017-02-28 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology |
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