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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Natera, José Massad, Walter García, Norman A. |
| Description | Country affiliation: Argentina Author Affiliation: Natera J ( Departamento de Química. Universidad Nacional de Río Cuarto, Campus Universitario, 5800 Río Cuarto, Argentina.) |
| Abstract | We report on the photostability of a mixture of vitamins B6 and B2 (riboflavin, Rf) upon visible light irradiation and on the possible role of the vitamin B6 family (B6D) as deactivators of reactive oxygen species (ROS). The work is a systematic kinetic and mechanistic study under conditions in which only Rf absorbs photoirradiation. Pyridoxine, pyridoxal hydrochloride, pyridoxal phosphate and pyridoxamine dihydrochloride were studied as representative members of the vitamin B6 family. The visible light irradiation of dissolved Rf and B6D in pH 7.4 aqueous medium under aerobic conditions induces photoprocesses that mainly produce B6D degradation. The overall oxidative mechanism involves the participation of ROS. Photogenerated (3)Rf* is quenched either by oxygen, giving rise to O(2)((1)Δ(g)) by electronic energy transfer to dissolved ground state oxygen, or by B6D yielding, through an electron transfer process, the neutral radical RfHË, and O(2)Ë(-) in an subsequent step. B6D act as quenchers of O(2)((1)Δ(g)) and O(2)Ë(-), the former in a totally reactive event that also inhibits Rf photoconsumption. The common chromophoric moiety of B6D represented by 3-hydroxypyridine, constitutes an excellent model that mimics the kinetic behavior of the vitamin as an antioxidant towards Rf-generated ROS. The protein lysozyme, taken as an O(2)((1)Δ(g))-mediated oxidizable biological target, is photoprotected by B6D from Rf-sensitized photodegradation through the quenching of electronically excited triplet state of the pigment, in a process that competes with O(2)((1)Δ(g)) generation. |
| File Format | HTM / HTML |
| ISSN | 1474905X |
| Issue Number | 6 |
| Volume Number | 11 |
| e-ISSN | 14749092 |
| Journal | Photochemical & Photobiological Sciences |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Publisher Date | 2012-06-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Chemistry Discipline Biology Antioxidants Chemistry Reactive Oxygen Species Riboflavin Vitamin B 6 Metabolism Radiation Effects Hydrogen-ion Concentration Kinetics Light Muramidase Oxidation-reduction Photolysis Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physical and Theoretical Chemistry |
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