NDLI: SNAP-25 single nucleotide polymorphisms are associated with hyperactivity in autism spectrum disorders.

Please wait, while we are loading the content...

The development of medicines for children. Part of a series on Pediatric Pharmacology, guest edited by Gianvincenzo Zuccotti, Emilio Clementi, and Massimo Molteni.

Intensity of macrolide anti-inflammatory activity in J774A.1 cells positively correlates with cellular accumulation and phospholipidosis.

Vasomodulatory effect of novel peroxovanadate compounds on rat aorta: Role of rho kinase and nitric oxide/cGMP pathway.

SNAP-25 single nucleotide polymorphisms are associated with hyperactivity in autism spectrum disorders.

Endogenous 2-oxoglutarate levels impact potencies of competitive HIF prolyl hydroxylase inhibitors.

Melatonin independent protective role of l-tryptophan in experimental reflux esophagitis in rats.

Thymidylate synthase expression and genotype have no major impact on the clinical outcome of colorectal cancer patients treated with 5-fluorouracil.

Extracellular Ca(2+) entry and mobilization of inositol trisphosphate-dependent Ca(2+) stores modulate histamine and electrical field stimulation induced contractions of the guinea-pig prostate.

In vitro inhibition of human and rat platelets by NO donors, nitrosoglutathione, sodium nitroprusside and SIN-1, through activation of cGMP-independent pathways.

2050: Ending the odyssey of the great white plague. Part of a series on Pediatric Pharmacology, guest edited by Gianvincenzo Zuccotti, Emilio Clementi, and Massimo Molteni.

The l-Ser analog #290 promotes bone recovery in OP and RA mice.

Beneficial effects of l-leucine and l-valine on arrhythmias, hemodynamics and myocardial morphology in rats.

North American ginseng protects the heart from ischemia and reperfusion injury via upregulation of endothelial nitric oxide synthase.

Nitric oxide, a janus-faced therapeutic target for diabetic microangiopathy-Friend or foe?

Year: 2011 Volume: 64 Issue: 2

Year: 2011 Volume: 64 Issue: 1

Year: 2011 Volume: 63

Year: 2010 Volume: 62

Year: 2010 Volume: 61

Year: 2009 Volume: 60

Year: 2009 Volume: 59

Year: 2008 Volume: 58

Year: 2008 Volume: 57

Year: 2007 Volume: 56

Year: 2007 Volume: 55

Year: 2006 Volume: 54

SNAP-25 single nucleotide polymorphisms are associated with hyperactivity in autism spectrum disorders.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Guerini, Franca R. Bolognesi, Elisabetta Chiappedi, Matteo Manca, Salvatorica Ghezzo, Alessandro Agliardi, Cristina Sotgiu, Stefano Usai, Sonia Matteoli, Michela Clerici, Mario
Description	Country affiliation: Italy Author Affiliation: Guerini FR ( Don C. Gnocchi Foundation ONLUS, P. le Morandi 6, 20121 Milano, Italy. fguerini@dongnocchi.it)
Abstract	Synaptosomal-associated protein of 25kD (SNAP-25), a protein participating in the regulation of synaptic vesicle exocytosis and in calcium homeostasis, was recently involved in neuropsychiatric conditions. Because alterations affecting the homeostasis of calcium are described in patients affected by autism spectrum disorders (ASD) we investigated a possible involvement of SNAP-25 in ASD by evaluating five SNAP-25 gene polymorphisms in a cohort of 67 ASD children. Data analyzed in relationship with clinical outcomes and compared to those of 205 healthy sex-matched children did not reveal significant differences. Further analyses nevertheless showed the presence of highly significant associations of the rs363043 (CT) genotype, localized in the intron 1 region that affects the transcription factor binding sites of the SNAP-25 gene, with both increasing CARS (p=0.001) and hyperactivity scores (p=0.006). The finding that polymorphisms of the SNAP-25 gene, a gene involved in neurotransmission and regulation of calcium homeostasis, are associated with the degree of hyperactivity in children with ASD, reinforces the hypothesis that alterations of these mechanisms play a pivotal role in the events leading to ASD-associated behavioral impairment. Modulation of these processes could result in novel therapeutic strategies.
File Format	HTM / HTML
ISSN	10436618
Issue Number	3
Volume Number	64
e-ISSN	10961186
Journal	Pharmacological Research
Language	English
Publisher	Elsevier
Publisher Date	2011-09-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Child Development Disorders, Pervasive Genetics Polymorphism, Single Nucleotide Synaptosomal-associated Protein 25 Adolescent Calcium Metabolism Child Cohort Studies Female Humans Male Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pharmacology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

An association study between SNAP-25 gene and attention-deficit hyperactivity disorder.

Synaptosomal-associated protein 25 (Snap-25) gene Polymorphism frequency in fibromyalgia syndrome and relationship with clinical symptoms

Polymorphisms in the FK506 binding protein 5 gene are associated with attention deficit hyperactivity disorder and diurnal cortisol levels

Gene expression of synaptosomal-associated protein 25 (SNAP-25) in the prefrontal cortex of the spontaneously hypertensive rat (SHR)

Possible association between the oxytocin receptor gene and N-acetylaspartate of the right medial temporal lobe in autism spectrum disorders.

Synaptosomal-associated protein 25 (SNAP-25) and attention deficit hyperactivity disorder (ADHD): evidence of linkage and association in the Irish population

Synaptosomal-Associated Protein 25 Gene Polymorphisms Affect Treatment Efficiency of Methylphenidate in Children With Attention-Deficit Hyperactivity Disorder: An fNIRS Study

Association with tryptophan hydroxylase 2 gene polymorphisms and autism spectrum disorders in Korean families.

Allele-specific associations of 5-HTTLPR/rs25531 with ADHD and autism spectrum disorder.

SNAP-25 single nucleotide polymorphisms are associated with hyperactivity in autism spectrum disorders.

Similar Documents

An association study between SNAP-25 gene and attention-deficit hyperactivity disorder.

Synaptosomal-associated protein 25 (Snap-25) gene Polymorphism frequency in fibromyalgia syndrome and relationship with clinical symptoms

Polymorphisms in the FK506 binding protein 5 gene are associated with attention deficit hyperactivity disorder and diurnal cortisol levels

Gene expression of synaptosomal-associated protein 25 (SNAP-25) in the prefrontal cortex of the spontaneously hypertensive rat (SHR)

Possible association between the oxytocin receptor gene and N-acetylaspartate of the right medial temporal lobe in autism spectrum disorders.

Synaptosomal-associated protein 25 (SNAP-25) and attention deficit hyperactivity disorder (ADHD): evidence of linkage and association in the Irish population

Synaptosomal-Associated Protein 25 Gene Polymorphisms Affect Treatment Efficiency of Methylphenidate in Children With Attention-Deficit Hyperactivity Disorder: An fNIRS Study

Association with tryptophan hydroxylase 2 gene polymorphisms and autism spectrum disorders in Korean families.

Allele-specific associations of 5-HTTLPR/rs25531 with ADHD and autism spectrum disorder.

SNAP-25 single nucleotide polymorphisms are associated with hyperactivity in autism spectrum disorders.