NDLI: Potential antipsoriatic effect of chondroitin sulfate through inhibition of NF-κB and STAT3 in human keratinocytes.

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Potential antipsoriatic effect of chondroitin sulfate through inhibition of NF-κB and STAT3 in human keratinocytes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Andrés, Rosa M. Payá, Miguel Montesinos, M. Carmen Ubeda, Amalia Navalón, Pedro Herrero, Marta Vergés, Josep Terencio, M. Carmen
Description	Country affiliation: Spain Author Affiliation: Andrés RM ( Department of Pharmacology, Faculty of Pharmacy, University of Valencia, Burjassot 46100, Spain.)
Abstract	Chondroitin sulfate (CS) is a natural glycosaminoglycan, formed by the 1-3 linkage of d-glucuronic acid to N-acetylgalactosamine, present in the extracellular matrix. It is used as a slow acting disease modifying agent in the treatment of osteoarthritis, and part of its beneficial effects are due to its antiinflammatory properties that result from an inhibitory effect on NF-κB signaling pathway. This ability raises the hypothesis that CS might be effective in other chronic inflammatory processes such as psoriasis, in which a deregulation of NF-κB is a key feature. In addition, psoriasis is characterized by an upregulation of STAT3 signaling pathway that is related to the epidermal hyperplasia. In the present study we report the pharmacological modulation of the NF-κB and STAT3 signaling pathways by CS in normal human keratinocytes. CS inhibited NF-κB activation and the release of some of the key psoriatic cytokines such as TNF , IL-8, IL-6 and CCL27. Moreover, it impaired STAT3 translocation to the nucleus and significantly reduced STAT3 transcriptional activity by a mechanism that was independent from STAT3 phosphorylation. Our results confirm the interest of CS as a candidate for future drug research in the therapeutics of psoriasis given the need of more effective and safer oral medications for these patients.
File Format	HTM / HTML
ISSN	10436618
Issue Number	1
Volume Number	70
e-ISSN	10961186
Journal	Pharmacological Research
Language	English
Publisher	Elsevier
Publisher Date	2013-04-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Anti-inflammatory Agents Pharmacology Chondroitin Sulfates Keratinocytes Drug Effects Nf-kappa B Antagonists & Inhibitors Psoriasis Drug Therapy Stat3 Transcription Factor Therapeutic Use Blotting, Western Cells, Cultured Dermoscopy Electrophoretic Mobility Shift Assay Humans Immunology Microscopy, Fluorescence Primary Cell Culture Protein Binding Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pharmacology

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