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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tinker, Andrew Finlay, Malcom Nobles, Muriel Opel, Aaisha |
| Description | Author Affiliation: Tinker A ( The Heart Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London EC1M6BQ, UK. Electronic address: a.tinker@qmul.ac.uk.); Finlay M ( The Heart Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London EC1M6BQ, UK.); Nobles M ( The Heart Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London EC1M6BQ, UK.); Opel A ( The Heart Centre, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London EC1M6BQ, UK.) |
| Abstract | Atrial fibrillation is the commonest cardiac arrhythmia and leads to significant clinical morbidity and mortality. It has a complex pathophysiology but is often initiated by atrial ectopic beats and because of atrial remodelling once it occurs it can become established. Thus therapeutic interventions designed to prevent the initial occurrence of the arrhythmia are particularly needed. At the cellular level, these ectopic beats arise because of abnormal calcium release events from the sarcoplasmic reticulum leading to an inward current mediated by the sodium-calcium exchanger. There has been considerable interest in this over the last few years largely focused on the ryanodine receptor and related signalling pathways. However, atrial myocytes also possess a well-developed inositol trisphosphate (IP3) dependent calcium release system and this has been less studied. In this review we focus on pathways and molecules that couple via the Gq 11 family of G-proteins including regulators of G-protein signalling that may influence IP3 mediated calcium release and atrial fibrillation. |
| File Format | HTM / HTML |
| ISSN | 10436618 |
| Volume Number | 105 |
| e-ISSN | 10961186 |
| Journal | Pharmacological Research |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Atrial Fibrillation Metabolism Calcium Gtp-binding Protein Alpha Subunits, Gq-g11 Inositol Phosphates Signal Transduction Animals Drug Therapy Pathology Drug Discovery Heart Atria Drug Effects Humans Molecular Targeted Therapy Myocytes, Cardiac Ryanodine Receptor Calcium Release Channel Journal Article Research Support, Non-u.s. Gov't Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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