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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Habold, Caroline Foltzer-Jourdainne, Charlotte Le Maho, Yvon Lignot, Jean-Hervé |
| Description | Country affiliation: France Author Affiliation: Habold C ( Centre d'Ecologie et Physiologie Energétiques, CNRS, 23 Rue Becquerel, 67087 Strasbourg Cedex 2, France. caroline.habold@c-strasbourg.fr) |
| Abstract | Intestinal apoptosis and expression of apoptosis inducers--the cytokines TNFalpha, TGFbeta1--and the intestinal transcription factor Cdx2, were studied according to two different metabolic and hormonal phases which characterize long-term fasting: the long period of protein sparing during which energy expenditure is derived from lipid oxidation (phase II), and the later phase characterized by a rise in body protein utilization and plasma corticosterone (phase III). Apoptosis was further studied in 2, 6, and 24 h refed rats. Morphological apoptotic events were observed by environmental and conventional scanning electron microscopy and a TUNEL test was used to characterize the final stages of apoptotic death. The gene and protein expressions of TNFalpha, TGFbeta1, and Cdx2 were measured. Apoptotic events and TNFalpha, TGFbeta1, and Cdx2 gene and protein expressions did not vary significantly during phase II as compared to the normally fed animals. However, a phase III fasting induced a delay in intestinal epithelial apoptosis, along with a 92, 58, and 25% decrease in TNFalpha, TGFbeta1, and Cdx2 mRNAs, respectively. The amounts of TNFalpha, TGFbeta1, and Cdx2 proteins decreased by 70, 36, and 25%, respectively. Apoptosis was restored rapidly after a 2 h refeeding following the phase III, accompanied by a significant increase in TNFalpha, TGFbeta1, and Cdx2 mRNA and the protein levels, compared to the phase III fasting values. The concomitant decreases in cytokines and Cdx2 and in apoptotic cells during phase III suggest the preservation of enterocytes during this critical fasting period in order to optimize nutrient absorption as soon as food is available and thus, to rapidly restore body mass. |
| File Format | HTM / HTML |
| ISSN | 00316768 |
| e-ISSN | 14322013 |
| Journal | Pflügers Archiv - European Journal of Physiology |
| Issue Number | 6 |
| Volume Number | 451 |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2006-03-01 |
| Publisher Place | Germany |
| Access Restriction | Open |
| Subject Keyword | Discipline Physiology Apoptosis Physiology Energy Metabolism Intestines Metabolism Animals Corticosterone Blood Cytokines Genetics Fasting Gene Expression Regulation Homeodomain Proteins Ultrastructure Rats, Wistar Transcription Factors Urea Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Physiology (medical) Clinical Biochemistry |
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