NDLI: Expression of renal and intestinal Na/Pi cotransporters in the absence of GABARAP.

Please wait, while we are loading the content...

In vivo stimulation of AMP-activated protein kinase enhanced tubuloglomerular feedback but reduced tubular sodium transport during high dietary NaCl intake

Expression of renal and intestinal Na/Pi cotransporters in the absence of GABARAP.

Impaired glycosylation blocks DPP10 cell surface expression and alters the electrophysiology of Ito channel complex.

Oxygen sensing and conducted vasomotor responses in mouse cremaster arterioles in situ

Nitric oxide lacks direct effect on TRPC5 channels but suppresses endogenous TRPC5-containing channels in endothelial cells

TRPM5 regulates glucose-stimulated insulin secretion

Calcium and calcimimetics regulate paracellular $Na^{+}$ transport in the thin ascending limb of Henle’s loop in mouse kidney

Regulation of the epithelial $Na^{+}$ channel and airway surface liquid volume by serine proteases

PGC-1alpha-mediated adaptations in skeletal muscle.

The presence of bestrophin-1 modulates the $Ca^{2+}$ recruitment from $Ca^{2+}$ stores in the ER

Electrophysiological characterization of store-operated and agonist-induced $Ca^{2+}$ entry pathways in endothelial cells

Year: 2010 Volume: 459

Year: 2009 Volume: 459

Year: 2009 Volume: 458

Year: 2009 Volume: 457

Year: 2008 Volume: 457

Year: 2008 Volume: 456

Year: 2008 Volume: 455

Year: 2007 Volume: 455

Year: 2007 Volume: 454

Year: 2007 Volume: 453

Year: 2006 Volume: 453

Year: 2006 Volume: 451

Year: 2005 Volume: 451

Year: 2004 Volume: 449

Year: 2003 Volume: 447

Year: 2000 Volume: 440

Year: 2000 Volume: 439

Year: 1989 Volume: 413

Year: 1987 Volume: 409

Expression of renal and intestinal Na/Pi cotransporters in the absence of GABARAP.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Reining, Sonja C. Liesegang, Annette Betz, Heinrich Biber, Jürg Murer, Heini Hernando, Nati
Description	Country affiliation: Switzerland Author Affiliation: Reining SC ( Institute of Physiology, University of Zurich, Winterthurerstr. 190, 8057, Zurich, Switzerland.)
Abstract	We have recently shown that the abundance of the renal sodium (Na)/inorganic phosphate (Pi) cotransporter NaPi-IIa is increased in the absence of the GABA(A) receptor-associated protein (GABARAP). Accordingly, GABARAP-deficient mice have a reduced urinary excretion of Pi. However, their circulating levels of Pi do not differ from wild-type animals, suggesting the presence of a compensatory mechanism responsible for keeping serum Pi values constant. Here, we aimed first to identify the molecular basis of this compensation by analyzing the expression of Na/Pi cotransporters known to be expressed in the kidney and intestine. We found that, in the kidney, the upregulation of NaPi-IIa is not accompanied by changes on the expression of either NaPi-IIc or PiT2, the other cotransporters known to participate in renal Pi reabsorption. In contrast, the intestinal expression of NaPi-IIb is downregulated in mutant animals, suggesting that a reduced intestinal absorption of Pi could contribute to maintain a normophosphatemic status despite the increased renal retention. The second goal of this work was to study whether the alterations on the expression of NaPi-IIa induced by chronic dietary Pi are impaired in the absence of GABARAP. Our data indicate that, in response to high Pi diets, GABARAP-deficient mice downregulate the expression of NaPi-IIa to levels comparable to those seen in wild-type animals. However, in response to low Pi diets, the upregulation of NaPi-IIa is greater in the mutant mice. Thus, both the basal expression and the dietary-induced upregulation of NaPi-IIa are increased in the absence of GABARAP.
File Format	HTM / HTML
ISSN	00316768
Issue Number	1
Volume Number	460
e-ISSN	14322013
Journal	Pflügers Archiv - European Journal of Physiology
Language	English
Publisher	Springer
Publisher Date	2010-06-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Physiology Cytoskeletal Proteins Deficiency Ileum Metabolism Kidney Membrane Proteins Phosphates Sodium-phosphate Cotransporter Proteins, Type Iia Sodium-phosphate Cotransporter Proteins, Type Iib Sodium Animals Bone Density Genetics Femur Gene Expression Regulation Intestinal Absorption Lumbar Vertebrae Male Mice Mice, Inbred C57bl Mice, Knockout Microvilli Blood Urine Phosphorus, Dietary Rna, Messenger Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Clinical Biochemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency.

Hypophosphatemia in vitamin D receptor null mice: effect of rescue diet on the developmental changes in renal $Na^{+}-dependent$ phosphate cotransporters

Acute parathyroid hormone differentially regulates renal brush border membrane phosphate cotransporters.

GABARAP deficiency modulates expression of NaPi-IIa in renal brush-border membranes.

Requirement of a leucine residue for (apical) membrane expression of type IIb NaPi cotransporters.

Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities.

Renal phosphaturia during metabolic acidosis revisited: molecular mechanisms for decreased renal phosphate reabsorption.

Intestinal npt2b plays a major role in phosphate absorption and homeostasis.

Intestinal phosphate transport.

Expression of renal and intestinal Na/Pi cotransporters in the absence of GABARAP.

Similar Documents

Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency.

Hypophosphatemia in vitamin D receptor null mice: effect of rescue diet on the developmental changes in renal $Na^{+}-dependent$ phosphate cotransporters

Acute parathyroid hormone differentially regulates renal brush border membrane phosphate cotransporters.

GABARAP deficiency modulates expression of NaPi-IIa in renal brush-border membranes.

Requirement of a leucine residue for (apical) membrane expression of type IIb NaPi cotransporters.

Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities.

Renal phosphaturia during metabolic acidosis revisited: molecular mechanisms for decreased renal phosphate reabsorption.

Intestinal npt2b plays a major role in phosphate absorption and homeostasis.

Intestinal phosphate transport.

Expression of renal and intestinal Na/Pi cotransporters in the absence of GABARAP.