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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lv, Yinglian Feng, Mei Che, Tongtong Sun, Hui Luo, Yan Liu, Kejing Liu, Chuanyong |
| Description | Author Affiliation: Lv Y ( Department of Physiology, Shandong University School of Medicine, Jinan 250012, People's Republic of China.) |
| Abstract | The aim of the present study was to investigate the effect of oxytocin (OT) on duodenum motility in rats and the possibility that cholecystokinin (CCK) was involved in this process. The isometric contraction of longitudinal muscle strips of duodenum was monitored by polygraph. ELISA was used to measure the concentration of CCK and OT in duodenum. CCK mRNA was assayed by RT-PCR. Oxytocin receptor (OTR) and CCK in duodenum were located by immunohistochemistry and immunofluorescence staining. OT $(10^{−5}$ and $10^{−6} M)$ inhibited the spontaneous contraction of the muscle strips. On the contrary, atosiban (OT receptor antagonist), lorglumide $(CCK_{1}$ receptor antagonist), and tetrodotoxin (TTX, blocker of voltage-dependent $Na^{+}$ channel on nerve fiber) excited the contraction. The inhibitory effect of OT on duodenal motility was reversed by pretreatment of atosiban, lorglumide, or TTX. Exogenous OT did not influence the expression of OT mRNA in duodenum but increased the concentration of CCK in the culture medium of the cells isolated from longitudinal muscle myenteric plexus. The OTR and CCK were co-expressed in the neurons of the myenteric plexus in duodenum. We concluded that OT inhibited the contraction of the LD spontaneous contraction of rats in vitro. This effect was mediated by the CCK released from the neurons of the myenteric plexus in duodenum. |
| File Format | HTM / HTML |
| ISSN | 00316768 |
| Issue Number | 6 |
| Volume Number | 460 |
| e-ISSN | 14322013 |
| Journal | Pflügers Archiv - European Journal of Physiology |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2010-11-01 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Physiology Cholecystokinin Pharmacology Duodenum Physiology Oxytocin Animals Biosynthesis Drug Effects Gastrointestinal Motility Male Muscle Contraction Myenteric Plexus Secretion Proglumide Analogs & Derivatives Rats Rats, Wistar Receptors, Cholecystokinin Antagonists & Inhibitors Receptors, Oxytocin Metabolism Tetrodotoxin Vasotocin Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Physiology (medical) Clinical Biochemistry |
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