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KRAS and BRAF mutations in sinonasal cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	López, Fernando García Inclán, Cristina Pérez-Escuredo, Jhudit Alvarez Marcos, César Scola, Bartolomé Suárez, Carlos Llorente, José Luis Hermsen, Mario A.
Description	Country affiliation: Spain Author Affiliation: López F ( Department of Otolaryngology, Instituto Universitario de Oncología del Principado de Asturias, Hospital Universitario Central de Asturias, Oviedo, Spain.)
Abstract	OBJECTIVES: [corrected] Despite improvements in the field of surgery and radiotherapy, the overall prognosis of sinonasal carcinomas is poor, mainly due to the difficulty to resect the tumour completely in this anatomically complex region. Therefore, there is great need for alternative treatments. Knowledge of the KRAS and BRAF mutational status would become clinically important with regard to the possible use of anti-EGFR therapies. MATERIAL AND METHODS: DNA was extracted from paraffin embedded tumour samples from 57 cases of sinonasal squamous cell carcinoma (SNSCC) and from fresh frozen tumour samples from 58 cases of intestinal-type sinonasal adenocarcinoma (ITAC). Point mutations were analysed for KRAS exon 2 (codons 12 and 13) and BRAF (exon 15, V600E) by direct sequencing. RESULTS: Neither KRAS nor BRAF showed any mutations in the SNSCC, whereas 7/58 (12%) ITAC harboured KRAS mutations and no BRAF mutations. All seven cases with KRAS mutation concerned well-differentiated and less aggressive (papillary and colonic type) ITAC, all patients being woodworkers and 4/7 tobacco smokers. CONCLUSION: Neither of SNSCCs carried mutations in KRAS and BRAF and a low frequency of KRAS mutation was found in ITAC. This suggests that KRAS and BRAF mutations play a limited role in the development of sinonasal cancer and that mutation analysis is not useful as a screening test for sensitivity to anti-EGFR therapy in sinonasal cancer.
File Format	HTM / HTML
ISSN	13688375
Issue Number	8
Volume Number	48
e-ISSN	18790593
Journal	Oral Oncology
Language	English
Publisher	Elsevier
Publisher Date	2012-08-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Oncology Adenocarcinoma Genetics Carcinoma, Squamous Cell Nose Neoplasms Proto-oncogene Proteins B-raf Proto-oncogene Proteins Ras Proteins Aged Aged, 80 And Over Exons Female Follow-up Studies Humans Male Middle Aged Point Mutation Proto-oncogene Proteins P21(ras) Sex Distribution Journal Article
Content Type	Text
Resource Type	Article
Subject	Oral Surgery Cancer Research Oncology

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