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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Petrella, C. Agostini, S. Alema', G. S. Casolini, P. Carpino, F. Giuli, C. Improta, G. Linari, G. Petrozza, V. Broccardo, M. |
| Description | Country affiliation: Italy Author Affiliation: Petrella C ( Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.) |
| Abstract | BACKGROUND: Cannabinoids (CBs) evoke their effects by activating the cannabinoid receptor subtypes CB1-r and CB2-r and exert anti-inflammatory effects altering chemokine and cytokine expression. Various cytokines and chemokines are produced and released by rodent pancreatic acini in acute pancreatitis. Although CB1-r and CB2-r expressed in rat exocrine pancreatic acinar cells do not modulate digestive enzyme release, whether they modulate inflammatory mediators remains unclear. We investigated the CB-r system role on exocrine pancreas in unstimulated conditions and during acute pancreatitis. METHODS: We evaluated in vitro and in vivo changes induced by WIN55,212 on the inflammatory variables amylasemia, pancreatic edema and morphology, and on acinar release and content of the cytokine interleukin-6 (IL-6) and chemokine monocyte chemo-attractant protein-1 (MCP-1) in untreated rats and rats with caerulein (CK)-induced pancreatitis. KEY RESULTS: In the in vitro experiments, WIN55,212 (10(-6) mol L(-1)) inhibited IL-6 and MCP-1 release from acinar cells of unstimulated rats and after CK-induced pancreatitis. In vivo, when rats were pretreated with WIN55,212 (2 mg kg(-1), intraperitoneally) before experimentally-induced pancreatitis, serum amylase, pancreatic edema and IL-6 and MCP-1 acinar content diminished and pancreatic morphology improved. Conversely, when rats with experimentally-induced pancreatitis were post-treated with WIN55,212, pancreatitis worsened. CONCLUSIONS & INFERENCES: These findings provide new evidence showing that the pancreatic CB1-r/CB2-r system modulates pro-inflammatory factor levels in rat exocrine pancreatic acinar cells. The dual, time-dependent WIN55,212-induced changes in the development and course of acute pancreatitis support the idea that the role of the endogenous CB receptor system differs according to the local inflammatory status. |
| File Format | HTM / HTML |
| ISSN | 13501925 |
| Issue Number | 11 |
| Volume Number | 22 |
| e-ISSN | 13652982 |
| Journal | Neurogastroenterology & Motility |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2010-11-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Neurogastroenterology Benzoxazines Pharmacology Cannabinoids Agonists Chemokine Ccl2 Antagonists & Inhibitors Interleukin-6 Morpholines Naphthalenes Pancreas Metabolism Pancreatitis Drug Therapy Amylases Blood Animals Body Water Ceruletide Edema Pathology Enzyme-linked Immunosorbent Assay Gastrointestinal Agents Male Drug Effects Chemically Induced Quinolines Rats Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Endocrine and Autonomic Systems Gastroenterology |
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