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Clinicopathologic analysis of renal biopsies after haematopoietic stem cell transplantation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chan, Gavin S. W. Lam, Man Fai Au, Wing Yan Chim, Stella Tse, Kai Chung Lo, Stanley H. K. Fung, Shing Hoi Lai, Kar Neng Chan, Kwok Wah
Spatial Coverage	Hong Kong
Description	Country affiliation: Hong Kong Author Affiliation: Chan GS ( Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong. gavinchansw@yahoo.com)
Abstract	AIM: The ever-growing number and increasing survival of haematopoietic stem cell transplantation (HSCT) allow better recognition of its associated renal injuries. We aimed to study the clinicopathologic features of renal biopsies after HSCT by reviewing 13 percutaneous renal biopsies in our institute (Queen Mary Hospital). METHODS: A retrospective clinicopathologic study of all renal biopsies archived to the Department of Pathology, Queen Mary Hospital during the period January 1999 to December 2006 was performed. Biopsies from patients with HSCT were selected. Clinical data on presentation and follow up were retrieved from hospital records and physicians. RESULTS: In the 8-year period, a total of 2233 native renal biopsies were archived. Thirteen renal biopsies were selected from 12 patients with HSCT (11 allogeneic, one autologous). All but one patient were male. The age at renal biopsy ranged from 7 to 63 years (median: 32 years). The median interval of renal biopsy after HSCT was 24 months (range 1-134 months). Evidence of graft-versus-host disease was found in nine patients. The most common presentation was significant proteinuria (10 cases) and renal impairment (eight cases). The predominant histological changes were membranous glomerulonephritis (n = 4) and thrombotic microangiopathy (n = 4). One case of focal segmental glomerulosclerosis, IgA nephropathy, minimal change disease, acute tubular necrosis and hypertensive nephrosclerosis were also recorded. Four of our patients died at 0-11 months after renal biopsy. Of the remaining eight patients with a mean follow up of 43.6 months (range, 10-98 months), chronic renal impairment were found in three (37.5%) patients and significant proteinuria also persisted in three. One patient had cytogenetic evidence of relapse of underlying haematological malignancy after HSCT. CONCLUSION: Among the various renal lesions after HSCT, membranous glomerulonephritis and thrombotic microangiopathy were the most common. Mechanisms of renal injury varied from graft-versus-host disease-associated immune complex deposition to non-immune complex injury on endothelial cells, glomerular epithelial cells and tubular epithelium. Pathologists and clinicians should attend to the histological and temporal heterogeneity of renal injury when managing patients after HSCT.
File Format	HTM / HTML
ISSN	13205358
Issue Number	4
Volume Number	13
e-ISSN	14401797
Journal	Nephrology
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2008-06-01
Publisher Place	Australia
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Nephrology Hematopoietic Stem Cell Transplantation Adverse Effects Kidney Diseases Pathology Kidney Adolescent Adult Biopsy Child Female Glomerulonephritis, Iga Etiology Glomerulonephritis, Membranous Glomerulosclerosis, Focal Segmental Graft Vs Host Disease Hong Kong Humans Mortality Male Middle Aged Nephrosclerosis Nephrosis, Lipoid Retrospective Studies Thrombosis Time Factors Journal Article
Content Type	Text
Resource Type	Article
Subject	Nephrology

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