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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sugano, Kiyohiko Kansy, Manfred Artursson, Per Avdeef, Alex Bendels, Stefanie Di, Li Ecker, Gerhard F. Faller, Bernard Fischer, Holger Gerebtzoff, Grégori Lennernaes, Hans Senner, Frank |
| Description | Country affiliation: United kingdom Author Affiliation: Sugano K ( Pfizer, Research Formulation, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK. kiyohiko.sugano@pfizer.com) |
| Abstract | The permeability of biological membranes is one of the most important determinants of the pharmacokinetic processes of a drug. Although it is often accepted that many drug substances are transported across biological membranes by passive transcellular diffusion, a recent hypothesis speculated that carrier-mediated mechanisms might account for the majority of membrane drug transport processes in biological systems. Based on evidence of the physicochemical characteristics and of in vitro and in vivo findings for marketed drugs, as well as results from real-life discovery and development projects, we present the view that both passive transcellular processes and carrier-mediated processes coexist and contribute to drug transport activities across biological membranes. |
| File Format | HTM / HTML |
| ISSN | 14741776 |
| Issue Number | 8 |
| Volume Number | 9 |
| e-ISSN | 14741784 |
| Journal | Nature Reviews Drug Discovery |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2010-08-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Discipline Biotechnology Cell Membrane Metabolism Drug Design Pharmaceutical Preparations Animals Biological Transport Biological Transport, Active Cell Membrane Permeability Humans Permeability Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Drug Discovery Pharmacology |
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