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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Jiang, Xu-Rong Song, An Bergelson, Svetlana Arroll, Thomas Parekh, Bhavin May, Kimberly Chung, Shan Strouse, Robert Mire-Sluis, Anthony Schenerman, Mark |
| Description | Country affiliation: United States Author Affiliation: Jiang XR ( Analytical Biochemistry, MedImmune, Gaithersburg, Maryland 20878, USA. jiangx@medimmune.com) |
| Abstract | The Fc (crystallizable fragment) region of therapeutic antibodies can have an important role in their safety and efficacy. Although much is known about the structure-activity relationship of antibodies and the factors that influence Fc effector functions, a process has not yet been defined to clearly delineate how Fc functionality should be assessed and controlled during antibody development and manufacturing. In this article, we summarize the current knowledge of antibody Fc functionality, provide a strategy for assessing the effector functions of different classes of therapeutic antibodies (including Fc fusion proteins) and propose a path for routine testing and controls for manufacturers of antibody products. |
| File Format | HTM / HTML |
| ISSN | 14741776 |
| Issue Number | 2 |
| Volume Number | 10 |
| e-ISSN | 14741784 |
| Journal | Nature Reviews Drug Discovery |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2011-02-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Discipline Biotechnology Antibodies Chemistry Therapeutic Use Immunoglobulin Fc Fragments Animals Antibodies, Monoclonal Crystallization Humans Recombinant Fusion Proteins Immunology Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Drug Discovery Pharmacology |
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