| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Borràs, Eva Cantó, Ester Choi, Meena Maria Villar, Luisa Álvarez-cermeño, José Carlos Chiva, Cristina Montalban, Xavier Vitek, Olga Comabella, Manuel Sabidó, Eduard |
| Description |
Author Affiliation: Borràs E ( From the Proteomics Unit, Centre de Regulació Genòmica (CRG), Dr. Aiguader 88, 08003 Barcelona, Spain); Cantó E ( ¶Servei de Neurologia-Neuroimmunologia. Centre d'Esclerosi Múltiple de Catalunya (Cemcat). Institut de Receca Vall d'Hebron (VHIR). Hospital Universitari Vall d'Hebron. Universitat Autònoma de Barcelona. Barcelona, Spain); Choi M ( âDepartment of Statistics, Purdue University, West Lafayette, IN, USA); Maria Villar L ( **Department of Neurology and Immunology, Hospital Ramón y Cajal, Ctra. de Colmenar Viejo, km. 9,100, Madrid, 28034, Spain.); Álvarez-Cermeño JC ( **Department of Neurology and Immunology, Hospital Ramón y Cajal, Ctra. de Colmenar Viejo, km. 9,100, Madrid, 28034, Spain.); Chiva C ( From the Proteomics Unit, Centre de Regulació Genòmica (CRG), Dr. Aiguader 88, 08003 Barcelona, Spain); Montalban X ( ¶Servei de Neurologia-Neuroimmunologia. Centre d'Esclerosi Múltiple de Catalunya (Cemcat). Institut de Receca Vall d'Hebron (VHIR). Hospital Universitari Vall d'Hebron. Universitat Autònoma de Barcelona. Barcelona, Spain); Vitek O ( âDepartment of Statistics, Purdue University, West Lafayette, IN, USA); Comabella M ( ¶Servei de Neurologia-Neuroimmunologia. Centre d'Esclerosi Múltiple de Catalunya (Cemcat). Institut de Receca Vall d'Hebron (VHIR). Hospital Universitari Vall d'Hebron. Universitat Autònoma de Barcelona. Barcelona, Spain); Sabidó E ( From the Proteomics Unit, Centre de Regulació Genòmica (CRG), Dr. Aiguader 88, 08003 Barcelona, Spain) |
| Abstract |
Multiple sclerosis is an inflammatory, demyelinating, and neurodegenerative disease of the central nervous system. In most patients, the disease initiates with an episode of neurological disturbance referred to as clinically isolated syndrome, but not all patients with this syndrome develop multiple sclerosis over time, and currently, there is no clinical test that can conclusively establish whether a patient with a clinically isolated syndrome will eventually develop clinically defined multiple sclerosis. Here, we took advantage of the capabilities of targeted mass spectrometry to establish a diagnostic molecular classifier with high sensitivity and specificity able to differentiate between clinically isolated syndrome patients with a high and a low risk of developing multiple sclerosis. Based on the combination of abundances of proteins chitinase 3-like 1 and ala-ß-his-dipeptidase in cerebrospinal fluid, we built a statistical model able to assign to each patient a precise probability of conversion to clinically defined multiple sclerosis. Our results are of special relevance for patients affected by multiple sclerosis as early treatment can prevent brain damage and slow down the disease progression. |
| File Format |
HTM / HTML |
| ISSN |
15359476 |
| e-ISSN |
15359484 |
| Journal |
Molecular & Cellular Proteomics |
| Issue Number |
1 |
| Volume Number |
15 |
| Language |
English |
| Publisher |
American Society for Biochemistry and Molecular Biology |
| Publisher Date |
2016-01-01 |
| Publisher Place |
United States |
| Access Restriction |
Open |
| Subject Keyword |
Discipline Proteomics Multiple Sclerosis Metabolism Nervous System Diseases Proteome Proteomics Adipokines Cerebrospinal Fluid Amino Acid Sequence Diagnosis, Differential Dipeptidases Disease Progression Lectins Mass Spectrometry Molecular Sequence Data Diagnosis Peptides Prognosis Classification Reproducibility Of Results Sensitivity And Specificity Syndrome Research Support, Non-u.s. Gov't |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Medicine Analytical Chemistry Molecular Biology Biochemistry |
