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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | García-Marqués, Fernando Trevisan-Herraz, Marco Martínez-Martínez, Sara Camafeita, Emilio Jorge, Inmaculada Lopez, Juan Antonio Méndez-Barbero, Nerea Méndez-Ferrer, Simón Del Pozo, Miguel Angel Ibáñez, Borja Andrés, Vicente Sánchez-Madrid, Francisco Redondo, Juan Miguel Bonzon-Kulichenko, Elena Vázquez, Jesús |
| Description | Country affiliation: Spain Author Affiliation: García-Marqués F ( From the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.); Trevisan-Herraz M ( From the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.); Martínez-Martínez S ( From the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.); Camafeita E ( From the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.); Jorge I ( From the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.); Lopez JA ( From the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.); Méndez-Barbero N ( From the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.); Méndez-Ferrer S ( From the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.); Del Pozo MA ( From the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.); Ibáñez B ( From the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.); Andrés V ( From the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.); Sánchez-Madrid F ( From the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.); Redondo JM ( From the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.); Bonzon-Kulichenko E ( From the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain ebonzon@cnic.es jvazquez@cnic.es.); Vázquez J ( From the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain ebonzon@cnic.es jvazquez@cnic.es.) |
| Abstract | The coordinated behavior of proteins is central to systems biology. However, the underlying mechanisms are poorly known and methods to analyze coordination by conventional quantitative proteomics are still lacking. We present the Systems Biology Triangle (SBT), a new algorithm that allows the study of protein coordination by pairwise quantitative proteomics. The Systems Biology Triangle detected statistically significant coordination in diverse biological models of very different nature and subjected to different kinds of perturbations. The Systems Biology Triangle also revealed with unprecedented molecular detail an array of coordinated, early protein responses in vascular smooth muscle cells treated at different times with angiotensin-II. These responses included activation of protein synthesis, folding, turnover, and muscle contraction - consistent with a differentiated phenotype-as well as the induction of migration and the repression of cell proliferation and secretion. Remarkably, the majority of the altered functional categories were protein complexes, interaction networks, or metabolic pathways. These changes could not be detected by other algorithms widely used by the proteomics community, and the vast majority of proteins involved have not been described before to be regulated by AngII. The unique capabilities of The Systems Biology Triangle to detect functional protein alterations produced by the coordinated action of proteins in pairwise quantitative proteomics experiments make this algorithm an attractive choice for the biological interpretation of results on a routine basis. |
| File Format | HTM / HTML |
| ISSN | 15359476 |
| e-ISSN | 15359484 |
| Journal | Molecular & Cellular Proteomics |
| Issue Number | 5 |
| Volume Number | 15 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology |
| Publisher Date | 2016-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Proteomics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Analytical Chemistry Molecular Biology Biochemistry |
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