NDLI: Twenty-four hour blood pressure pattern in patients with normal tension glaucoma in the habitual position.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Joe, Soo Geun Choi, Jaewan Sung, Kyung Rim Park, Seong Bae Kook, Michael S.
Description	Author Affiliation: Joe SG ( Department of Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea.)
Abstract	PURPOSE: To investigate the relationship between blood pressure (BP) parameters in the habitual position and glaucomatous damage at initial presentation in patients with untreated normal tension glaucoma (NTG). METHODS: Fifty-four eyes from 54 subjects diagnosed with NTG were consecutively enrolled. BP was measured with an automated ambulatory monitoring device in the habitual position during 24-hour in-hospitalization. Patients were classified into three groups: non-dippers, dippers, and over-dippers. corresponded to the degree of reduction in their nocturnal mean arterial pressure (MAP) compared with their diurnal MAP. Regression models were used to evaluate potential risk factors, including: age, pre-admission office intraocular pressure (IOP), central corneal thickness (CCT), and BP parameters. Functional outcome variables for glaucomatous damage included mean deviation (MD) and pattern standard deviation (PSD) on a Humphrey field analyzer (HFA). Anatomic outcome variables were TSNIT score (temporal, superior, nasal, inferior, and temporal) average, superior average, inferior average, and nerve fiber indicator (NFI) score on scanning laser polarimetry with variable corneal compensation (SLP-VCC; GDx-VCC). RESULTS: Marked systolic blood pressure (SBP), diastolic blood pressure (DBP), and MAP fluctuation were noted in the over-dipper group (p<0.05). A linear regression analysis model revealed that nocturnal trough DBP and MAP, average nocturnal SBP, and MAP were all significantly associated with a decreased average TSNIT score and an increased NFI score. CONCLUSIONS: Nocturnal BP reduction estimated in the habitual position was associated with structural damage in eyes with NTG. This finding may suggest systemic vascular etiology of NTG development associated with nocturnal BP reduction.
File Format	HTM / HTML
ISSN	10118942
e-ISSN	20929382
DOI	10.3341/kjo.2009.23.1.32
Journal	Korean Journal of Ophthalmology
Issue Number	1
Volume Number	23
Language	English
Publisher	Korean Ophthalmological Society
Publisher Date	2009-03-01
Publisher Place	Korea (South)
Access Restriction	Open
Subject Keyword	Discipline Ophthalmology Blood Pressure Monitoring, Ambulatory Blood Pressure Physiology Circadian Rhythm Glaucoma, Open-angle Physiopathology Posture Disease Progression Diagnosis Intraocular Pressure Nerve Fibers Pathology Prognosis Prospective Studies Retina Risk Factors Visual Fields Comparative Study
Content Type	Text
Resource Type	Article
Subject	Ophthalmology

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