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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kang, Purum Seol, Geun Hee |
| Description | Author Affiliation: Kang P ( Department of Basic Nursing Science, School of Nursing, Korea University, Seoul, Korea.) |
| Abstract | OBJECTIVES: The aim of this study was to investigate the cardiovascular relaxing properties of monoterpene alcohol (-)-linalool (LIN), a principal component of several aromatic plants. METHODS: We assessed the effects of LIN on vascular contractility in mouse aortae and evaluated its underlying mechanisms of action. KEY FINDINGS: We found that LIN dose-dependently relaxed the vascular tonus of mouse thoracic aortae induced by prostaglandin F2 alpha (PGF2 , 3 µm). This effect, however, was reduced by pretreatment with the nitric oxide synthase inhibitor L-NAME (30 µm). Treatment with the inhibitor of soluble guanylyl cyclase ODQ (2 µm) or the K(+) channel blocker TEA (10 mM) partially blocked LIN-induced vasorelaxation. Moreover, addition of TEA after incubation of the rings with L-NAME and ODQ partially blocked LIN-induced vasorelaxation. Furthermore, LIN was able to partially antagonize CaCl2 -induced contractions in high potassium (80 mM) Krebs' solution, whereas LIN did not affect Ca(2+) release from endoplasmic reticulum Ca(2+) stores. CONCLUSION: Our findings indicate that LIN may induce endothelium-dependent vasorelaxation in mouse thoracic aortae by activating soluble guanylyl cyclase and K(+) channels. |
| File Format | HTM / HTML |
| ISSN | 00223573 |
| Issue Number | 5 |
| Volume Number | 67 |
| e-ISSN | 20427158 |
| Journal | Journal of Pharmacy and Pharmacology |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2015-05-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Aorta Drug Effects Guanylate Cyclase Metabolism Monoterpenes Pharmacology Potassium Channels Vasodilation Animals Calcium Calcium Chloride Antagonists & Inhibitors Dinoprost Dose-response Relationship, Drug Endoplasmic Reticulum Enzyme Activation Male Mice Ng-nitroarginine Methyl Ester Oxadiazoles Quinoxalines Tetraethylammonium Vasodilator Agents Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Pharmaceutical Science |
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