NDLI: Genistein selectively inhibits estrogen-induced cell proliferation and other responses to hormone stimulation in the prepubertal rat uterus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gaete, Leonardo Tchernitchin, Andrei N. Bustamante, Rodrigo Villena, Joan Lemus, Igor Gidekel, Manuel Cabrera, Gustavo Carrillo, Omar
Description	Country affiliation: Chile Author Affiliation: Gaete L ( 1Laboratory of Experimental Endocrinology and Environmental Pathology, Institute of Biomedical Sciences (ICBM), University of Chile Medical School, Santiago, Chile.)
Abstract	Sex hormone replacement therapy helps improve quality of life in climacteric women. However, estrogen-induced cell proliferation in the uterus and mammary gland increases the risk for cancer in these organs. The lower incidence of mammary cancer in Asian women than in western women has been attributed to high intake of soy isoflavones, including genistein. Our previous work in the prepubertal rat uterus model showed that genistein (0.5 mg/kg body weight subcutaneously) caused an estradiol-like hypertrophy in myometrial and uterine luminal epithelial cells and an increase in RNA content in luminal epithelium; however, it did not induce cell proliferation, uterine eosinophilia, or endometrial edema. The present study investigated, in the same animal model, the effect of genistein administration (0.5 mg/kg body weight subcutaneously) before treatment with estradiol-17ß (0.33 mg/kg body weight subcutaneously) on uterine responses that were not induced by genistein. Pretreatment with this phytoestrogen completely inhibited estradiol-induced mitoses in uterine luminal epithelium, endometrial stroma, and myometrium and partially inhibited estradiol-induced uterine eosinophilia and endometrial edema. These findings indicate that genistein protects against estrogen-induced cell proliferation in the uterus and suggest that future studies should investigate the possibility of using this agent to decrease the risk for uterine cancer after hormone replacement therapy in climacteric women.
File Format	HTM / HTML
ISSN	1096620X
Issue Number	12
Volume Number	14
e-ISSN	15577600
Journal	Journal of Medicinal Food
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2011-12-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Nutritional Sciences Cell Proliferation Drug Effects Estrogens Pharmacology Genistein Administration & Dosage Phytoestrogens Uterus Animals Anticarcinogenic Agents Endometrium Epithelium Estradiol Female Hormones Metabolism Isoflavones Menopause Myometrium Rats Rats, Sprague-dawley Risk Factors Beta-glucans Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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