NDLI: Hypoglycemic and antioxidant activities of paeonol and its beneficial effect on diabetic encephalopathy in streptozotocin-induced diabetic rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Liu, Jiping Wang, Shuyuan Feng, Liang Ma, Dongying Fu, Qiang Song, Yu Jia, Xiaobin Ma, Shiping
Description	Country affiliation: China Author Affiliation: Liu J ( Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, China.)
Abstract	Diabetic encephalopathy (DE) is one of the severe complications in patients with diabetes mellitus. Paeonol, an active compound isolated from the root bark of Paeonia suffruticosa, has significant antidiabetic activity in vivo. However, its underlying beneficial effects on DE were unclear. In the present study, the protective activity of paeonol on DE was evaluated in streptozotocin (STZ)-induced diabetic rats. Paeonol at 50 and 100 mg/kg significantly increased body weight and decreased blood glucose levels, glycosylated serum proteins, and serum advanced glycation end products (AGEs) levels. Immunohistochemistry assays and Western blot analysis revealed a significant decrease in expressions on receptor for advanced glycation end products (RAGE) and nuclear factor kappa B (NF-κB) in hippocampus and cerebral cortical neurons after paeonol treatment. Furthermore, paeonol significantly increased glutathione content and remarkedly decreased induced nitric oxide synthase activity in hippocampus tissue. Our findings indicated that paeonol could improve the pathological damage of DE in STZ-induced diabetic rats. It might be associated with the modulating AGEs/RAGE/NF-κB pathway. This study suggested that paeonol might be a promising candidate for the prevention and treatment of DE.
File Format	HTM / HTML
ISSN	1096620X
Issue Number	7
Volume Number	16
e-ISSN	15577600
Journal	Journal of Medicinal Food
Language	English
Publisher	Mary Ann Liebert, Inc.
Publisher Date	2013-07-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Nutritional Sciences Antioxidants Administration & Dosage Brain Diseases, Metabolic Drug Therapy Diabetes Mellitus, Experimental Complications Diabetes Mellitus, Type 2 Hypoglycemic Agents Paeonia Chemistry Animals Etiology Genetics Metabolism Glycosylation End Products, Advanced Humans Male Nf-kappa B Oxidative Stress Drug Effects Rats Rats, Sprague-dawley Streptozocin Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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