NDLI: A multicentre, randomized, double-blind trial of the safety and efficacy of mannose-6-phosphate in patients having Zone II flexor tendon repairs.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lees, V. C. Warwick, D. Gillespie, P. Brown, A. Akhavani, M. Dewer, D. Boyce, D. Papanastasiou, S. Ragoowansi, R. Wong, J.
Description	Country affiliation: United kingdom Author Affiliation: Lees VC ( University Hospital South Manchester, Manchester, UK.); Warwick D ( Southampton General Hospital, Southampton, UK.); Gillespie P ( Addenbrookes Hospital, Cambridge, UK.); Brown A ( Ulster Hospital, Belfast, UK.); Akhavani M ( Royal Free Hospital, London, UK.); Dewer D ( Royal Free Hospital, London, UK.); Boyce D ( Morriston Hospital, Swansea, UK.); Papanastasiou S ( Lister Hospital, Stevenage, UK.); Ragoowansi R ( Royal London Hospital, London, UK.); Wong J ( University Hospital South Manchester, Manchester, UK jason.k.wong@manchester.ac.uk.)
Abstract	The safety, tolerability and preliminary efficacy of mannose 6-phosphate in enhancing the outcome in Zone II flexor tendon repair was studied in a multicentre parallel double-blinded randomized controlled trial. Eight UK teaching hospitals were involved in treating repaired flexor tendons with a single intraoperative intrathecal dose of 600 mM mannose 6-phosphate, with follow-up over 26 weeks. A total of 39 patients (mannose 6-phosphate, n = 20; standard care, n = 19) were randomized. Seven were excluded from the safety and tolerability analysis because of intraoperative findings and eight were excluded due to early dropout (n = 4) or tendon rupture (n = 4), leaving 24 (mannose 6-phosphate, n = 13; standard care, n = 11) for assessment of total active motion. The safety, tolerability and other side effects were comparable between the groups. There was no significant difference between the two groups in the total active motion at Week 26. We concluded that mannose 6-phosphate, although safe and tolerable, had no beneficial effect on finger range of motion after Zone II tendon division.Level of evidence 1b.
File Format	HTM / HTML
ISSN	17531934
Issue Number	7
Volume Number	40
e-ISSN	20436289
Journal	Journal of Hand Surgery (European Volume)
Language	English
Publisher	Sage Publication
Publisher Date	2015-09-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Trautomology Discipline General Surgery Finger Injuries Surgery Mannosephosphates Administration & Dosage Tendon Injuries Tissue Adhesions Prevention & Control Adult Aged Double-blind Method Female Humans Injections Male Middle Aged Range Of Motion, Articular Transforming Growth Factor Beta Antagonists & Inhibitors Young Adult Journal Article Multicenter Study Randomized Controlled Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Surgery

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