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  1. Journal of Biomedical Materials Research Part B: Applied Biomaterials
  2. Year: 2007 Volume: 81
  3. Year: 2007 Volume: 81 Issue: 1
  4. Sensate scaffolds can reliably detect joint loading.
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Effects of Incorporating Nanosized Calcium Phosphate Particles on Properties of Whisker-Reinforced Dental Composites
Sensate scaffolds can reliably detect joint loading.
Year: 2007 Volume: 80
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Sensate scaffolds can reliably detect joint loading.

Content Provider World Health Organization (WHO)-Global Index Medicus
Author Bliss, C. L. Szivek, J. A. Tellis, B. C. Margolis, D. S. Schnepp, A. B. Ruth, J. T.
Description Country affiliation: United States Author Affiliation: Bliss CL ( Orthopedic Research Laboratory, Department of Surgery, University of Arizona, Tucson, Arizona 85724, USA. cbliss@u.arizona.edu)
Abstract Treatment of cartilage defects is essential to the prevention of osteoarthritis. Scaffold-based cartilage tissue engineering shows promise as a viable technique to treat focal defects. Added functionality can be achieved by incorporating strain gauges into scaffolds, thereby providing a real-time diagnostic measurement of joint loading. Strain-gauged scaffolds were placed into the medial femoral condyles of 14 adult canine knees and benchtop tested. Loads between 75 and 130 N were applied to the stifle joints at 30 degrees, 50 degrees, and 70 degrees of flexion. Strain-gauged scaffolds were able to reliably assess joint loading at all applied flexion angles and loads. Pressure sensitive films were used to determine joint surface pressures during loading and to assess the effect of scaffold placement on joint pressures. A comparison of peak pressures in control knees and joints with implanted scaffolds, as well as a comparison of pressures before and after scaffold placement, showed that strain-gauged scaffold implantation did not significantly alter joint pressures. Future studies could possibly use strain-gauged scaffolds to clinically establish normal joint loads and to determine loads that are damaging to both healthy and tissue-engineered cartilage. Strain-gauged scaffolds may significantly aid the development of a functional engineered cartilage tissue substitute as well as provide insight into the native environment of cartilage.
File Format HTM / HTML
ISSN 15524973
e-ISSN 15524981
Journal Journal of Biomedical Materials Research Part B: Applied Biomaterials
Issue Number 1
Volume Number 81
Language English
Publisher Wiley
Publisher Date 2007-04-01
Publisher Place United States
Access Restriction Open
Subject Keyword Discipline Biomedical engineering Cartilage, Articular Knee Joint Physiology Knee Prosthesis Materials Testing Tissue Engineering Animals Femur Osteoarthritis Therapy Stress, Mechanical Surface Properties Tibia Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type Text
Resource Type Article
Subject Biomaterials Biomedical Engineering
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