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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Evjenth, Bjørg Hansen, Tonje E. Holt, Jan |
| Description | Author Affiliation: Evjenth B ( a Department of Pediatrics, Division of Pediatrics , Obstetrics and Women's Health, Nordland Hospital , Bodø , Norway and.) |
| Abstract | OBJECTIVE: Fractional exhaled nitric oxide (FENO) and exercise testing are widely used for the evaluation of pediatric asthma. The evidence relating to the effects of strenuous exercise on FENO in children is conflicting. Little information is available on the association between exercise and FENO in relation to allergic rhinoconjunctivitis (AR). We aimed to investigate the effects of AR on children's FENO in response to a standardized treadmill exercise test. METHODS: A total of 124 children with current asthma and 124 non-asthmatic children aged 8-16 years were studied. FENO was measured at baseline, at 1 and 30 min after an exercise challenge test using the single breath technique with EcoMedics Exhalyzer. A structured parental interview, spirometry, serum allergen-specific IgE and skin prick tests were performed. RESULTS: Baseline FENO was higher in both asthmatics and non-asthmatics with AR than without AR (both p < 0.001). The FENO time trend was dependent on AR (p = 0.039), irrespective of asthma (p = 0.876). In children with AR, FENO had declined at 1 min by a mean of 6.1 ppb with a 95% confidence level of 5.1-7.5 ppb; at 30 min, the reduction was 2.8 (2.5-3.3) ppb. In children without AR, at 1 min the decline in FENO was 2.7 (2.1-3.5) ppb and by 30 min post-exercise it was 1.6 (1.3-2.0) ppb. CONCLUSIONS: The impact of exercise on FENO was dependent on the allergic phenotype, regardless of asthma status. FENO decreased immediately after exercise, and did not return to baseline level within 30 min. |
| File Format | HTM / HTML |
| ISSN | 02770903 |
| Issue Number | 8 |
| Volume Number | 52 |
| e-ISSN | 15324303 |
| Journal | Journal of Asthma |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2015-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pulmonology Conjunctivitis, Allergic Metabolism Exercise Physiology Nitric Oxide Rhinitis, Allergic Adolescent Allergens Immunology Child Blood Physiopathology Female Forced Expiratory Volume Humans Immunoglobulin E Male Skin Tests Spirometry Controlled Clinical Trial Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine Immunology and Allergy Pediatrics, Perinatology and Child Health |
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