NDLI: Drug reaction with eosinophilia and systemic symptoms: observations from a tertiary care institution.

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Drug reaction with eosinophilia and systemic symptoms: observations from a tertiary care institution.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sasidharanpillai, Sarita Riyaz, Najeeba Rajan, Uma Binitha, Manikoth P. Khader, Anza Mariyath, Olasseri K. Reena John, Rajiv Puravoor, Jayasree
Description	Country affiliation: India Author Affiliation: Sasidharanpillai S ( Department of Dermatology and Venereology, Govt Medical College, Kozhikode, Kerala, India.)
Abstract	BACKGROUND: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe drug reaction which can mimic a viral infection, an autoimmune disease or a neoplastic disease. AIMS: To study the clinical and epidemiological aspects of DRESS and to identify the precipitating drugs. METHODS: All patients admitted to the dermatology ward of our tertiary care hospital from 1 st October 2010 to 30 th September 2013 with probable or definite DRESS as per the RegiSCAR scoring system were included in this prospective study. The clinical manifestations observed in the study population were studied and the common offending drugs were identified. RESULTS: During the 3 year study period, 26 patients fulfilled criteria for probable or definite DRESS. In more than 50% of cases, the culprit drug was phenytoin. Most common symptoms observed were fever, rash and facial edema. Liver was the most common internal organ affected. Most of the patients responded to withdrawal of the drug and administration of steroids for 3-6 weeks. One patient with dapsone-induced DRESS died. CONCLUSIONS: Intense facial erythema and edema and an elevated eosinophil count were not found to be bad prognostic factors. In most instances the flare ups during the course of the disease could be managed with a slower tapering of steroids. More prospective studies on DRESS are required to assess the prognostic factors and to formulate better diagnostic criteria.
File Format	HTM / HTML
ISSN	03786323
e-ISSN	09733922
Journal	Indian Journal of Dermatology, Venereology, and Leprology
Issue Number	3
Volume Number	80
Language	English
Publisher	Medknow Publications
Publisher Date	2014-05-01
Publisher Place	India
Access Restriction	Open
Subject Keyword	Discipline Sexually Transmitted Diseases Discipline Tropical Medicine Discipline Dermatology Dapsone Adverse Effects Drug Hypersensitivity Syndrome Diagnosis Etiology Phenytoin Tertiary Care Centers Adolescent Anti-infective Agents Anticonvulsants Child, Preschool Eosinophils Cytology Prospective Studies Observational Study
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Dermatology

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