NDLI: The effect of the combination of bisphosphonates and conventional chemotherapy on bone metabolic markers in multiple myeloma patients.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Xi Chang, Chunkang Zhao, Youshan Wu, Lingyun Zhang, Zheng Li, Xiao
Description	Country affiliation: China Author Affiliation: Zhang X ( Shanghai Sixth People's Hospital, Shanghai, China.)
Abstract	PURPOSE: Urinary N-terminal telopeptides of type I collagen (uNTX), serum bone alkaline phosphatase (sBAP) have been acknowledged in observing bone metastases of solid tumors. The paper is designed to study the value of clinical application of uNTX and sBAP in the treatment of multiple myeloma (MM), as well as the action of bisphosphonates for osteolytic bone lesion. METHODOLOGY: Thirty-three MM cases were treated with bisphosphonates (hereinafter called clodronate therapy group) and 20 MM cases were treated with simple chemotherapy (hereinafter called control group). uNTX and sBAP were tested during the courses of treatment three times (pretreatment, 3 months, and 6 months). uNTX was tested by enzyme-linked immunosorbent assay. sBAP was tested by chemiluminescence analysis. All the results were analyzed with t-test by using SPSS 11.0. RESULTS: There were no significant differences between therapy and control groups: in uNTX (173.74 ± 14.55) and (129.79 ± 12.13) µg/l before treatment (P > 0.05). After 6 months there were significant differences between them: (85.71 ± 8.23) and (121.59 ± 12.43) µg/l (P < 0.05). And also there were significant differences among the courses in the therapy group. There were no significant differences between therapy and control groups in sBAP concentration: (4.78 ± 0.55) and (8.42 ± 1.32) µg/l before treatment (P > 0.05). After 6 months there were significant differences between them: (16.01 ± 0.52) and (9.62 ± 1.29) µg/l (P < 0.001). And also there were significant differences among the courses in the therapy group. CONCLUSION: uNTX and sBAP were important to measure the situation of the osteolytic bone lesion in MM. Bisphosphonates can significantly reduce bone degradation and metabolism, improve the synthesis, which is valuable for the treatment of MM cases.
File Format	HTM / HTML
ISSN	10245332
Issue Number	5
Volume Number	17
e-ISSN	16078454
Journal	Hematology
Language	English
Publisher	Taylor & Francis
Publisher Date	2012-09-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Hematology Alkaline Phosphatase Blood Antineoplastic Combined Chemotherapy Protocols Administration & Dosage Tumor Markers, Biological Bone Density Conservation Agents Bone Neoplasms Collagen Type I Diphosphonates Multiple Myeloma Osteolysis Peptides Adult Aged Drug Therapy Pathology Secondary Female Humans Male Middle Aged Neoplasm Metastasis Journal Article Randomized Controlled Trial
Content Type	Text
Resource Type	Article
Subject	Hematology

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