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Heart fatty acid binding protein (H-FABP) as a diagnostic biomarker in patients with acute coronary syndrome.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gururajan, Priya Gurumurthy, Prema Nayar, Pradeep Srinivasa Nageswara Rao, G. Babu, Sai Cherian, K. M.
Description	Country affiliation: India Author Affiliation: Gururajan P ( International Centre for Cardiothoracic and Vascular Diseases, Department of Biochemistry, Dr K.M Cherian Heart Foundation (A Unit of Frontier LifeLine Pvt Ltd), R-30C, Ambattur Industrial Estate Road, Mogappair, Chennai 600 101, India.)
Abstract	AIMS AND OBJECTIVES: Diagnosis of myocardial ischaemia at an early stage in the emergency department is often difficult. A recently proposed biomarker, heart fatty acid binding protein (H-FABP) has been found to appear in the circulation superior to that of cardiac troponins in the early hours of acute coronary syndrome. We proposed to evaluate the levels of H-FABP and ascertain its utility as an early biomarker for acute coronary syndrome (ACS). METHODS AND RESULTS: The present study was carried out in 485 subjects, of whom 297 were diagnosed as patients with ACS, 89 were diagnosed as non-cardiac chest pain (NCCP) and 99 people served as healthy controls. H-FABP levels were measured in comparison with standard markers such as troponin I and CK-MB in all subjects enrolled in the study. The levels of H-FABP were significantly raised in patients when compared to controls and NCCP (P<0.001). Receiver Operator Characteristic Curve (ROC) analysis showed H-FABP to be a good discriminator between patients with ischaemic heart disease and patients without ischaemic heart disease. The area under the curve was found to be 0.965 with 95% CI (0.945-0.979). The cut-off value above which H-FABP can be considered positive was found to be 17.7ng/ml. CONCLUSION: H-FABP is a promising biomarker for the early detection of patients with acute coronary syndrome.
File Format	HTM / HTML
ISSN	14439506
Issue Number	11
Volume Number	19
e-ISSN	14442892
Journal	Heart, Lung and Circulation
Language	English
Publisher	Elsevier
Publisher Date	2010-11-01
Publisher Place	Australia
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Cardiology Acute Coronary Syndrome Blood Diagnosis Biological Markers Fatty Acid-binding Proteins Myocardial Infarction Adult Aged Early Diagnosis Electrocardiography Female Humans Male Middle Aged Sensitivity And Specificity Statistics, Nonparametric Troponin I Clinical Trial Journal Article
Content Type	Text
Resource Type	Article
Subject	Pulmonary and Respiratory Medicine Cardiology and Cardiovascular Medicine

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