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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Andréasson, H. Graf, W. Nygren, P. Glimelius, B. Mahteme, H. |
| Spatial Coverage | Sweden |
| Description | Country affiliation: Sweden Author Affiliation: Andréasson H ( Department of Surgical Sciences, Section of Surgery, Uppsala University, S-751 85 Uppsala, Sweden. hakan.andreasson@surgsci.uu.se) |
| Abstract | BACKGROUND: The aim of this study was to compare debulking surgery and cytoreductive surgery (CRS) in patients with Pseudomyxoma peritonei (PMP) regarding efficacy and safety. PATIENTS AND METHODS: Data were extracted from medical records and treatment outcomes were analyzed for all 152 patients with PMP who were scheduled for debulking surgery and intraperitoneal chemotherapy (IPC) or CRS and IPC at Uppsala University Hospital, Uppsala, Sweden, between September 1993 and December 2008. RESULTS: One hundred and ten patients (73%) were treated with CRS and IPC and 40 (27%) with debulking surgery and IPC. In two patients (1%), surgery was defined as open and close. Patients with CRS and IPC had a 74% 5-year overall survival (OS) rate compared with 40% for those treated with debulking surgery (P < 0.001). Patients with no residual macroscopic tumour (R1 resection) had a better 5-year OS rate of 94% compared with 28% for patients with macroscopic residual tumour (R2) (P < 0.001). Grades II-IV adverse events were seen in 29% of debulked patients and in 47% of CRS/IPC patients (P = 0.053). CONCLUSIONS: CRS and IPC seems more efficient than debulking surgery and IPC but with numerically higher morbidity. Therefore, if surgically possible, CRS should be the treatment of choice for PMP patients. However, debulking surgery may still be of benefit to selected patients for palliative purposes. |
| File Format | HTM / HTML |
| ISSN | 07487983 |
| Issue Number | 10 |
| Volume Number | 38 |
| Journal | European Journal of Surgical Oncology (EJSO) |
| e-ISSN | 15322157 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline General Surgery Discipline Oncology Digestive System Surgical Procedures Methods Peritoneal Neoplasms Drug Therapy Surgery Pseudomyxoma Peritonei Adult Aged Antineoplastic Combined Chemotherapy Protocols Therapeutic Use Biopsy, Needle Cohort Studies Databases, Factual Mortality Disease-free Survival Female Follow-up Studies Humans Immunohistochemistry Infusions, Parenteral Male Middle Aged Neoplasm Invasiveness Pathology Neoplasm Staging Odds Ratio Peritoneum Retrospective Studies Risk Assessment Statistics, Nonparametric Survival Analysis Sweden Treatment Outcome Young Adult Comparative Study Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Surgery Oncology |
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