NDLI: Genome-wide screening of indicator genes for assessing the potential carcinogenic risk of Nanjing city drinking water.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Rui Cheng, Shupei Li, Aimin Sun, Jie Zhang, Yan Zhang, Xuxiang
Spatial Coverage	China
Description	Author Affiliation: Zhang R ( State Key Laboratory of Pollution Control & Resource Reuse, School of the Environment, Nanjing University, 163 Xianlin Road, Nanjing, 210046, People's Republic of China.)
Abstract	Effects of all pollutants existing in the Nanjing city drinking water (DWNC) on mouse gene transcription levels were measured to assess the DWNC carcinogenic risks and to identify candidate indicator genes for assessing and early warning the cancer risks. Transcriptional expression levels of 14,000 hepatic genes for the treatment group mice (Mus musculus, ICR) fed with DWNC for 90 days were detected using the GeneChip(®) Mouse Genome 430A 2.0 array. The analysis indicated that the transcriptional levels of 294 genes were up-regulated and 542 ones were down-regulated. Of these genes, 12 ones identified to be involved in at least five different types of cancers were further analyzed. An interrogation by Kyoto Encyclopedia of Genes and Genomes (KEGG) revealed that three (including ITGAV, CCND1 and SMAD2) of the 12 genes were mapped to pathway in cancer. Gene Ontology (GO) function annotation also showed that they were associated with the functional categories of cell cycle regulation, adhesion, apoptosis, signal transduction and so on which are closely implicated in tumorigenesis and progression. The correlations between the aberrant expressions of them and the genesis and progression of cancers have been further documented by a number of scientific researches. These results might demonstrate that the potential toxicity and carcinogenic risks were associated with DWNC. Moreover, ITGAV, CCND1 and SMAD2 were identified as the most likely candidate indicator genes for the assessment of the combined carcinogenic risk of all pollutants existing in DWNC.
File Format	HTM / HTML
ISSN	09639292
Issue Number	5
Volume Number	20
e-ISSN	15733017
Journal	Ecotoxicology
Language	English
Publisher	Springer
Publisher Date	2011-07-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Ecology Discipline Environmental Health Discipline Toxicology Carcinogens, Environmental Toxicity Water Pollutants, Chemical Water Supply Analysis Animals Biological Markers Metabolism China Cyclin D1 Genetics Environmental Monitoring Methods Fresh Water Chemistry Gene Expression Drug Effects Male Mice Mice, Inbred Icr Risk Assessment Smad2 Protein Statistics & Numerical Data Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Management, Monitoring, Policy and Law

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Genome-wide screening of indicator genes for assessing the potential carcinogenic risk of Nanjing city drinking water

Integration of gene chip and topological network techniques to screen a candidate biomarker gene (CBG) for predication of the source water carcinogenesis risks on mouse Mus musculus.

Assessing the toxicity of ingested Taihu Lake water on mice via hepatic histopathology and matrix metalloproteinase expression.

Reproductive toxicity in male mice exposed to Nanjing City tap water.

Health Risk from Exposure of Organic Pollutants Through Drinking Water Consumption in Nanjing, China

Serum biochemical analysis to indicate pathogenic risk on mouse Mus musculus exposure to source of drinking water.

Non-carcinogenic risk assessment of eight metals in the source groundwater of Shaying River basin.

Assessment of carcinogenic and non-carcinogenic risk lead in bottled water in different age groups in Bandar Abbas Ciry, Iran.

Mouse organ coefficient and abnormal sperm rate analysis with exposure to tap water and source water in Nanjing reach of Yangtze River.

Genome-wide screening of indicator genes for assessing the potential carcinogenic risk of Nanjing city drinking water.

Similar Documents

Genome-wide screening of indicator genes for assessing the potential carcinogenic risk of Nanjing city drinking water

Integration of gene chip and topological network techniques to screen a candidate biomarker gene (CBG) for predication of the source water carcinogenesis risks on mouse Mus musculus.

Assessing the toxicity of ingested Taihu Lake water on mice via hepatic histopathology and matrix metalloproteinase expression.

Reproductive toxicity in male mice exposed to Nanjing City tap water.

Health Risk from Exposure of Organic Pollutants Through Drinking Water Consumption in Nanjing, China

Serum biochemical analysis to indicate pathogenic risk on mouse Mus musculus exposure to source of drinking water.

Non-carcinogenic risk assessment of eight metals in the source groundwater of Shaying River basin.

Assessment of carcinogenic and non-carcinogenic risk lead in bottled water in different age groups in Bandar Abbas Ciry, Iran.

Mouse organ coefficient and abnormal sperm rate analysis with exposure to tap water and source water in Nanjing reach of Yangtze River.

Genome-wide screening of indicator genes for assessing the potential carcinogenic risk of Nanjing city drinking water.