NDLI: Reconsidering sufficient and optimal test design in acute toxicity testing.

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Reconsidering sufficient and optimal test design in acute toxicity testing.

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Reconsidering sufficient and optimal test design in acute toxicity testing.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jager, Tjalling
Description	Author Affiliation: Jager T ( Department of Theoretical Biology, VU University Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands, tjalling.jager@vu.nl.)
Abstract	In dose-response analysis, regression analysis and hypothesis testing are the main tools of choice. These methods, however, have specific requirements for the design of acute toxicity experiments. To produce meaningful results, both approaches require a constant exposure concentration over the duration of the test, and regression analysis makes an additional demand for at least two doses with partial mortality at the end of the test. These requirements, however, result from the limitations of the statistical techniques, which only use the observations at the end of the test. In practice, most standard protocols for acute testing prescribe that observations are made at several points in time (often daily). In this contribution, I demonstrate how dynamic modelling can make use of this information to produce robust estimates of LC50 as function of time, with confidence intervals, from data sets that violate the requirements for standard dose-response analysis. This form of modelling invites an entirely different, more flexible, view on experimental design, which could lead to a more efficient use of test animals and, at the same time, a stronger support for environmental risk assessment as well as the science of ecotoxicology.
File Format	HTM / HTML
ISSN	09639292
Issue Number	1
Volume Number	23
e-ISSN	15733017
Journal	Ecotoxicology
Language	English
Publisher	Springer
Publisher Date	2014-01-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Ecology Discipline Environmental Health Discipline Toxicology Models, Biological Toxicity Tests, Acute Methods Water Pollutants, Chemical Toxicity Amphipoda Drug Effects Animals Cyprinidae Metabolism Diazinon Dose-response Relationship, Drug Hydrocarbons, Chlorinated Insecticides Lethal Dose 50 Naphthalenes Risk Assessment Evaluation Studies Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Management, Monitoring, Policy and Law

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