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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Alkhamis, Khouloud A. |
| Description | Country affiliation: Jordan Author Affiliation: Alkhamis KA ( Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan. khou@just.edu.jo) |
| Abstract | It was of interest to investigate the solid-state acidity using indicator probe molecules and sucrose degradation. Amorphous samples containing lactose, sucrose, buffers (citrate, malate, tartarate, or phosphate) with different pH values, and sodium chloride (to adjust the ionic strength) were prepared by freeze-drying. The lyophiles were characterized using powder X-ray diffraction, differential scanning calorimetry, and Karl Fischer titrimetry. The solid-state acidity of all lyophiles was measured using diffuse reflectance spectroscopy and suitable indicators (thymol blue or bromophenol blue). Selected lyophiles were subjected to a temperature of 60 degrees C and were analyzed for sucrose degradation using the Trinder kit. The results obtained from this study have shown that good correlation can be obtained between the solid-state acidity and the molar ratio of the salt and the acid in solution. The degradation of sucrose in the lyophiles is extremely sensitive to the solid-state acidity and might be able to provide a better estimate for the acidity than the indicator probe molecules. The Hammett acidity-rate profile for sucrose degradation in the lyophiles (using four different buffers) was also obtained. The profile showed similarity to the pH-rate profile in solution, and no buffer catalysis for sucrose degradation was detected in this study. |
| File Format | HTM / HTML |
| ISSN | 03639045 |
| Issue Number | 4 |
| Volume Number | 35 |
| e-ISSN | 15205762 |
| Journal | Drug Development and Industrial Pharmacy |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2009-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Chemistry, Pharmaceutical Methods Sucrose Chemistry Buffers Drug Stability Freeze Drying Hydrogen-ion Concentration Kinetics Models, Chemical Osmolar Concentration Phase Transition Solutions Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science |
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