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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mehanna, Mohammed M. Elmaradny, Hoda A. Samaha, Magda W. |
| Description | Country affiliation: Egypt Author Affiliation: Mehanna MM ( Industrial Pharmacy Department, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt. dr_mehanna@yahoo.com) |
| Abstract | Management of extraocular diseases is mainly limited by the inability to provide long-term drug delivery without avoiding the systemic drug exposure and/or affecting the intraocular structures and poor availability of drugs, which may be overcome by prolonging the contact time with the ocular system, for instance with liposomes. Development and optimization of reverse phase evaporation ciprofloxacin (CPF) HCl liposomes for ocular drug delivery was carried out using a 2(5) full factorial design based on five independent variables. The effects of the studied parameters on drug entrapment efficiency (EE), particle size, and percentage of drug released after 1 and 10 h were investigated. The results obtained pointed out that the molar concentration of cholesterol was the predominant factor that increased the EE% of the drug and the particle size responses. The percentage of drug released after 1 h was significantly controlled by the initial CPF concentration while that after 10 h was controlled by molar cholesterol concentration. The designed liposomes had average particle sizes that ranged from 2.5 to 7.23 microm. In addition, liposomes revealed a fast release during the first hour followed by a more gradual drug release during the 24-h period according to Higuchi diffusion model. |
| File Format | HTM / HTML |
| ISSN | 03639045 |
| Issue Number | 5 |
| Volume Number | 35 |
| e-ISSN | 15205762 |
| Journal | Drug Development and Industrial Pharmacy |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2009-05-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Anti-bacterial Agents Administration & Dosage Ciprofloxacin Liposomes Chemistry Ophthalmic Solutions Algorithms Analysis Of Variance Chemistry, Pharmaceutical Cholesterol Drug Carriers Drug Delivery Systems Drug Design Endocytosis Excipients Hydrogen-ion Concentration Kinetics Models, Statistical Organophosphates Particle Size Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science |
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