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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wahlgren, Marie Christensen, Karin Löwenstein Jørgensen, Erik Valentin Svensson, Anna Ulvenlund, Stefan |
| Description | Country affiliation: Sweden Author Affiliation: Wahlgren M ( Division of Food Technology, Department of Food Engineering, Lund University, Lund, Sweden. marie.wahlgren@food.lth.se) |
| Abstract | AIM: To investigate the release of hydrophobic and hydrophilic substances from tablets containing Pemulen and Carbopol as excipients. METHOD: The dissolution patterns of a hydrophobic (diazepam) and a hydrophilic active substance (midodrine-HCl) from different tablet formulations containing a nonmodified polyacrylic microgel (Carbopol 981 F) or a hydrophobically modified polyacrylic microgel (Pemulen) have been studied. Possible differences in dissolution in phosphate buffer (pH 6.8) and in 0.1 M HCl between tablets produced using wet granulation and direct compression were also investigated. RESULTS: Tablets produced by wet granulation had a greater effect on the release of active substance from the tablets. No major differences were observed in the release patterns of the hydrophilic substance midodrine-HCl from wet granulated tablets based on Carbopol and Pemulen. However, the release pattern of the more hydrophobic drug substance, diazepam, differed considerably between the two polymers. Wet granulation gave reproducible release patterns. The release patterns from the polymers differed considerably at pH 6.8 but were similar at low pH. CONCLUSIONS: The release of the diazepam from the hydrophobic polymer Pemulen was very slow, and the release was close to zero order. |
| File Format | HTM / HTML |
| ISSN | 03639045 |
| Issue Number | 8 |
| Volume Number | 35 |
| e-ISSN | 15205762 |
| Journal | Drug Development and Industrial Pharmacy |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2009-08-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Acrylic Resins Chemistry Diazepam Administration & Dosage Drug Carriers Midodrine Administration, Oral Adrenergic Alpha-agonists Delayed-action Preparations Gels Hydrogen-ion Concentration Hydrophobic And Hydrophilic Interactions Hypnotics And Sedatives Solubility Tablets Comparative Study Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science |
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