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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wokovich, Anna Tyner, Katherine Doub, William Sadrieh, Nakissa Buhse, Lucinda F. |
| Description | Country affiliation: United States Author Affiliation: Wokovich A ( Food and Drug Administration, Center for Drug Evaluation and Research, St. Louis, MO 63101, USA. anna.wokovich@fda.hhs.gov) |
| Abstract | BACKGROUND: There has been some apprehension expressed in the scientific literature that nanometer-sized titanium dioxide (TiO(2)) and other nanoparticles, if able to penetrate the skin, may cause cytotoxicity. In light of a lack of data regarding dermal penetration of titanium dioxide from sunscreen formulations, the Food and Drug Administration Center for Drug Evaluation and Research initiated a study in collaboration with the National Center for Toxicology Research using minipigs to determine whether nanoscale TiO(2) in sunscreen products can penetrate intact skin. Four sunscreen products were manufactured. METHOD: The particle size distribution of three TiO(2) raw materials, a sunscreen blank (no TiO(2)) and three sunscreen formulations containing uncoated nanometer-sized TiO(2), coated nanometer-sized TiO(2) or sub-micron TiO(2) were analyzed using scanning electron microscopy (SEM), laser scanning confocal microscopy (LSCM), and X-ray diffraction (XRD) to determine whether the formulation process caused a change in the size distributions (e.g., agglomeration or deagglomeration) of the TiO(2). RESULTS: SEM and XRD of the formulated sunscreens containing nanometer TiO(2) show the TiO(2) particles to have the same size as that observed for the raw materials. This suggests that the formulation process did not affect the size or shape of the TiO(2) particles. CONCLUSION: Because of the resolution limit of optical microscopy, nanoparticles could not be accurately sized using LSCM, which allows for detection but not sizing of the particles. LSCM allows observation of dispersion profiles throughout the sample; therefore, LSCM can be used to verify that results observed from SEM experiments are not solely surface effects. |
| File Format | HTM / HTML |
| ISSN | 03639045 |
| Issue Number | 10 |
| Volume Number | 35 |
| e-ISSN | 15205762 |
| Journal | Drug Development and Industrial Pharmacy |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2009-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Nanoparticles Sunscreening Agents Chemistry Titanium Chemistry, Pharmaceutical Methods Microscopy, Confocal Microscopy, Electron, Scanning Particle Size Permeability Skin Absorption Adverse Effects Pharmacokinetics X-ray Diffraction Comparative Study Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science |
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