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Formulation and optimization of a novel oral fast dissolving film containing drug nanoparticles by Box-Behnken design-response surface methodology.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Shen, Chengying Shen, Baode Xu, He Bai, Jinxia Dai, Ling Lv, Qingyuan Han, Jin Yuan, Hailong
Description	Country affiliation: China Author Affiliation: Shen C ( 302 Hospital of PLA&PLA Institute of Chinese Materia Medica , Beijing , China .)
Abstract	OBJECTIVE: The purpose of this study was to design and optimize a novel drug nanoparticles-loaded oral fast dissolving film (NP-OFDF) using Box-Behnken design-response surface methodology. METHODS: Drug nanosuspensions produced from high pressure homogenization were transformed into oral fast dissolving film containing drug nanoparticles by casting methods. Herpetrione (HPE), a novel and potent antiviral agent with poor water solubility that was extracted from Herpetospermum caudigerum, was studied as the model drug. The formulations of oral fast dissolving film containing HPE nanoparticles (HPE-NP-OFDF) were optimized by employing Box-Behnken design-response surface methodology and then systematically characterized. RESULTS: The optimized HPE-NP-OFDF was disintegrated in water within 20 s with reconstituted nanosuspensions particle size of 299.31 nm. Scanning electron microscopy (SEM) images showed that well-dispersed HPE nanoparticles with slight adhesion to each other were exposed on the surface of film or embedded in film. The X-ray diffractogram (XRD) analysis suggested that HPE in the HPE-NP-OFDF was in the amorphous state. In-vitro release study, approximate 77.23% of HPE was released from the HPE-NP-OFDF within 5 min, which was more than eight times compared with that of HPE raw materials (9.57%). CONCLUSION: The optimized HPE-NP-OFDF exhibits much faster drug release rates compared to HPE raw material, which indicated that this novel NP-OFDF may provide a potential opportunity for oral delivery of drugs with poor water solubility.
File Format	HTM / HTML
ISSN	03639045
Issue Number	5
Volume Number	40
e-ISSN	15205762
Journal	Drug Development and Industrial Pharmacy
Language	English
Publisher	Taylor & Francis
Publisher Date	2014-05-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Administration, Oral Drug Delivery Systems Nanoparticles Administration & Dosage Antiviral Agents Pharmacokinetics Chemistry, Pharmaceutical Furans Humans Microscopy, Electron, Scanning Models, Biological Ultrastructure Particle Size Solubility Surface Properties Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science

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