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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Patel, Hiren Joshi, Abhay Joshi, Amit Stagni, Grazia |
| Description | Country affiliation: United States Author Affiliation: Patel H ( a Division of Pharmaceutical Sciences , Arnold and Marie Schwartz College of Pharmacy, Long Island University , Brooklyn , NY , USA.); Joshi A ( a Division of Pharmaceutical Sciences , Arnold and Marie Schwartz College of Pharmacy, Long Island University , Brooklyn , NY , USA.); Joshi A ( a Division of Pharmaceutical Sciences , Arnold and Marie Schwartz College of Pharmacy, Long Island University , Brooklyn , NY , USA.); Stagni G ( a Division of Pharmaceutical Sciences , Arnold and Marie Schwartz College of Pharmacy, Long Island University , Brooklyn , NY , USA.) |
| Abstract | Skin pretreatment with a microneedle roller (microporation (MP)) appears a simple and inexpensive technique to increase transdermal delivery of topically applied drug products. This study investigates the effect of MP on the passive and iontophoretic delivery of diclofenac (DCF) by quantifying dermis and plasma levels of DCF in a rabbit model. New Zealand albino female rabbits received either: (i) a topical application of 4 g of Voltaren® 1% gel with or without pretreatment with a microroller (0.5 mm needle length; density 23 microneedles per cm(2) area) or (ii) a DCF solution (40 mg/2.5 mL) via iontophoresis (IOMED transQ(E) medium size patch), with or without microroller pretreatment. A 300 µA/cm(2) cathodic current was applied for 20 min for a total of 80 mA. DCF concentrations were monitored in dermis with microdialysis sampling every 20 min for 5 h. Plasma samples were collected over the same period. In the passive delivery studies, microroller pretreatment increased Cmax by 1.5- and 2.0-fold in skin and plasma, respectively, and AUC by 1.5- and 2.4-fold in skin and plasma, respectively. In the iontophoresis delivery studies, microporation increased Cmax by 2.0-fold both in skin and in plasma, and AUC by 1.1- and 1.8-fold in skin and plasma, respectively. In conclusion, microneedle pretreatment increased significantly the systemic exposure of DCF from either passive or iontophoretic delivery, whereas the effect in skin was less pronounced. |
| File Format | HTM / HTML |
| ISSN | 03639045 |
| Issue Number | 12 |
| Volume Number | 41 |
| e-ISSN | 15205762 |
| Journal | Drug Development and Industrial Pharmacy |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2015-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Diclofenac Metabolism Drug Delivery Systems Methods Iontophoresis Microdialysis Skin Absorption Physiology Administration, Cutaneous Animals Anti-inflammatory Agents, Non-steroidal Administration & Dosage Female Organ Culture Techniques Rabbits Drug Effects Transdermal Patch Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science |
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