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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Colecchia, Antonio Di Biase, Anna Rita Scaioli, Eleonora Predieri, Barbara Iughetti, Lorenzo Reggiani, Maria Letizia Bacchi Montrone, Lucia Ceccarelli, Pier Luca Vestito, Amanda Viola, Laura Paolucci, Paolo Festi, Davide |
| Description | Country affiliation: Italy Author Affiliation: Colecchia A ( Department of Clinical Medicine, University of Bologna, Italy. antonio.colecchia@aosp.bo.it) |
| Abstract | BACKGROUND: After a Kasai procedure, 70% of patients with biliary atresia develop chronic liver disease with portal hypertension and oesophageal varices. AIMS: To investigate the role of new non-invasive parameters in predicting the presence of varices in patients with biliary atresia after a Kasai procedure and to identify the cut-off values of these parameters in predicting the presence of varices. METHODS: 31 patients with biliary atresia who had undergone a Kasai portoenterostomy were studied. Clinical, biochemical and abdominal ultrasound examination, liver stiffness measurement (LSM), LSM-spleen diameter to platelet ratio score (LSPS) and upper digestive endoscopy were performed. RESULTS: 15 (47%) patients had oesophageal varices (Group A) and 16 had no varices (Group B). Median values of LSM (kPa) and LSPS were significantly higher in Group A than in Group B (LSM: 17.0 vs. 7.5, respectively; p=0.0001; LSPS: 19.62 vs. 2.94, respectively; p=0.0001). The optimal cut-offs for predicting oesophageal varices were: LSM>10.6 kPa (sensitivity: 87%, specificity: 87.5%, PPV: 87%, NPV: 87.5%, and AUC: 0.92) and LSPS ≥9.2 (sensitivity: 91%, specificity: 92%, PPV: 91%, NPV: 92%, and AUC: 0.96). CONCLUSIONS: Non-invasive methods can predict the presence of oesophageal varices in patients with biliary atresia; the sequential use of two non-invasive methods improves accuracy. |
| File Format | HTM / HTML |
| ISSN | 15908658 |
| Issue Number | 8 |
| Volume Number | 43 |
| e-ISSN | 18783562 |
| Journal | Digestive and Liver Disease |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-08-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Gastroenterology Biliary Atresia Surgery Elasticity Physiology Esophageal And Gastric Varices Diagnosis Liver Physiopathology Portoenterostomy, Hepatic Adverse Effects Adolescent Adult Complications Blood Platelets Child Child, Preschool Etiology Female Humans Metabolism Logistic Models Male Predictive Value Of Tests Roc Curve Spleen Anatomy & Histology Ultrasonography Young Adult Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hepatology Gastroenterology |
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