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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pica, Roberta Cassieri, Claudio Cocco, Andrea Zippi, Maddalena Marcheggiano, Adriana De Nitto, Daniela Avallone, Eleonora Veronica Crispino, Pietro Occhigrossi, Giuseppe Paoluzi, Paolo |
| Description | Author Affiliation: Pica R ( IBD Unit, Division of Gastroenterology and Digestive Endoscopy, Sandro Pertini Hospital, Rome, Italy. Electronic address: roberta.pica@aslromab.it.); Cassieri C ( Department of Internal Medicine and Medical Specialties, Gastroenterology Unit, 'Sapienza', University of Rome, Italy.); Cocco A ( IBD Unit, Division of Gastroenterology and Digestive Endoscopy, Sandro Pertini Hospital, Rome, Italy.); Zippi M ( IBD Unit, Division of Gastroenterology and Digestive Endoscopy, Sandro Pertini Hospital, Rome, Italy.); Marcheggiano A ( Department of Internal Medicine and Medical Specialties, Gastroenterology Unit, 'Sapienza', University of Rome, Italy.); De Nitto D ( IBD Unit, Division of Gastroenterology and Digestive Endoscopy, Sandro Pertini Hospital, Rome, Italy.); Avallone EV ( Department of Internal Medicine and Medical Specialties, Gastroenterology Unit, 'Sapienza', University of Rome, Italy.); Crispino P ( Department of Internal Medicine and Medical Specialties, Gastroenterology Unit, 'Sapienza', University of Rome, Italy.); Occhigrossi G ( IBD Unit, Division of Gastroenterology and Digestive Endoscopy, Sandro Pertini Hospital, Rome, Italy.); Paoluzi P ( Department of Internal Medicine and Medical Specialties, Gastroenterology Unit, 'Sapienza', University of Rome, Italy.) |
| Abstract | BACKGROUND: Mesalazine is used as maintenance therapy in ulcerative colitis but the optimal dosage is still controversial. AIM: To compare the remission-maintenance efficacy and tolerability of two daily doses of oral mesalazine (4.8 g and 2.4 g) in patients with ulcerative colitis with frequent relapses in a randomized controlled trial. METHODS: 112 ulcerative colitis patients in remission were enrolled and randomly allocated to treatment for 1 year with oral mesalazine at a daily dose of 4.8 g (n=56, Group A) or 2.4 g (n=56, Group B). RESULTS: At the end of the 12 months, intention to treat analysis revealed persistent remission in 42 (75%) in Group A and 36 (64.2%) in Group B (p=0.3). The higher daily dose (4.8 g) proved to be significantly more effective for maintaining remission in patients under 40 years of age (90.5% Group A vs. 50% Group B; Fisher's exact test, p=0.0095) and in those with extensive disease (90.9% Group A vs. 46.7% Group B; Fisher's exact test, p=0.0064). CONCLUSIONS: In ulcerative colitis patients younger than 40 years and/or with extensive disease, a daily dose of 4.8 g oral mesalazine results in increased rates and duration of remission compared to 2.4 g. |
| File Format | HTM / HTML |
| ISSN | 15908658 |
| Issue Number | 11 |
| Volume Number | 47 |
| e-ISSN | 18783562 |
| Journal | Digestive and Liver Disease |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-11-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Gastroenterology Anti-inflammatory Agents, Non-steroidal Administration & Dosage Colitis, Ulcerative Drug Therapy Maintenance Chemotherapy Methods Mesalamine Administration, Oral Adult Aged Aged, 80 And Over Biopsy Pathology Colonoscopy Female Humans Male Medication Adherence Middle Aged Recurrence Single-blind Method Treatment Outcome Comparative Study Journal Article Randomized Controlled Trial |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hepatology Gastroenterology |
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