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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Dailey, G. |
| Description | Country affiliation: United States Author Affiliation: Dailey G ( Department of Diabetes and Endocrinology, Scripps Clinic Torrey Pines, San Diego, CA 92037, USA. dailey.george@scrippshealth.org) |
| Abstract | The management of type 2 diabetes mellitus (T2DM) typically focuses on correcting dysglycaemia to reduce risk for microvascular and macrovascular complications, possibly by reducing glucose-mediated oxidative stress. However, other cardiometabolic risk factors, including abdominal obesity and dyslipidaemia are often overlooked in the quest for perfect glucose control. The currently used antidiabetic agents, including insulin, metformin, sulphonylureas and thiazolidinediones, have limited efficacy on these risk factors. A number of new therapeutic agents are undergoing clinical development, including glucagon-like peptide 1 mimetics (exenatide and liraglutide) and dipeptidyl peptidase 4 inhibitors (sitagliptin and vildagliptin), which target the incretin system, and the cannabinoid-1 receptor antagonists (rimonabant), which target the endocannabinoid system, may hold some promise for meeting these unmet needs. In this review, the clinical properties of these agents and potential treatment pathways to best use these agents are discussed for improving the management of T2DM and cardiovascular risk. |
| File Format | HTM / HTML |
| ISSN | 14628902 |
| Issue Number | Suppl 2 |
| Volume Number | 10 |
| e-ISSN | 14631326 |
| Journal | Diabetes, Obesity and Metabolism |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2008-07-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Metabolism Discipline Endocrinology Discipline Pharmacology Discipline Diabetology Cannabinoid Receptor Antagonists Cardiovascular Diseases Prevention & Control Diabetes Mellitus, Type 2 Drug Therapy Dipeptidyl-peptidase Iv Inhibitors Therapeutic Use Glucagon-like Peptide 1 Antagonists & Inhibitors Hypoglycemic Agents Weight Gain Drug Effects Complications Physiopathology Humans Obesity Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology |
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