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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Garber, A. J. |
| Description | Country affiliation: United States Author Affiliation: Garber AJ ( Division of Endocrinology, Diabetes and Metabolism, Baylor College of Medicine, Houston, TX 77030, USA. agarber@bcm.tmc.edu) |
| Abstract | The glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide is indicated as an add-on to oral antidiabetic drug regimens in subjects with type 2 diabetes. Herein, the results of clinical trials assessing the efficacy, safety and tolerability of liraglutide when used in combination with either one or two oral antidiabetic therapies are summarised, then contrasted with the effects of exenatide and dipeptidyl peptidase (DPP-4) inhibitors. GLP-1 receptor agonists lead to effective glycaemic control when used as combination therapy with either one or two oral antidiabetic agents, and may confer overall benefits in weight loss and blood pressure in some subjects. These agents are well tolerated; the most commonly reported adverse effect is mild-to-moderate gastrointestinal symptoms, which are usually transient. Rates of hypoglycaemia in these trials were low, although higher rates were noted when combined with a sulphonylurea. While further study will be required, GLP-1 receptor agonists may offer important advantages over other diabetic therapies, including DPP-4 inhibitors. |
| File Format | HTM / HTML |
| ISSN | 14628902 |
| Issue Number | Suppl 2 |
| Volume Number | 14 |
| e-ISSN | 14631326 |
| Journal | Diabetes, Obesity and Metabolism |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2012-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Metabolism Discipline Endocrinology Discipline Pharmacology Discipline Diabetology Diabetes Mellitus, Type 2 Drug Therapy Glucagon-like Peptide 1 Analogs & Derivatives Hypoglycemic Agents Therapeutic Use Receptors, Glucagon Agonists Administration, Oral Blood Glucose Drug Effects Blood Dipeptidyl-peptidase Iv Inhibitors Drug Therapy, Combination Female Administration & Dosage Adverse Effects Glucagon-like Peptide-1 Receptor Humans Liraglutide Male Peptides Randomized Controlled Trials As Topic Treatment Outcome Venoms Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology |
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