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Association of ß-cell function and insulin sensitivity with fasting and 2-h plasma glucose in a large Chinese population.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bi, Y. Zeng, L. Zhu, D. Yan, J. Zhang, Y. Tong, G. Mu, P. Shen, S. Hu, Y. Yu, Q. Liang, H. Weng, J.
Spatial Coverage	China
Description	Country affiliation: China Author Affiliation: Bi Y ( Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, China.)
Abstract	AIM: Our aim was to provide a quantitative analysis of the changes in the principal determinants of insulin sensitivity and secretion in relation to fasting plasma glucose (FPG) or 2-h plasma glucose (2h PG) in a Chinese population with a wide range of glucose tolerance. METHODS: A total of 5728 adults spanning the entire range of glucose tolerance were included. Insulin sensitivity was measured by Matsuda insulin sensitivity index (ISI(M)) and homeostasis model assessment of 1/homeostasis model assessment of insulin resistance (HOMA-IR). ß-Cell function adjusted by insulin sensitivity was assessed from disposition index (DI) at early-phase DI(30) and total DI(120). The exponential curve was established as the best fit for the relationship between insulin sensitivity or ß-cell function and FPG or 2h PG. RESULTS: Relative to the trend classified as increasing 2h PG, hepatic insulin sensitivity and insulin secretion showed a decreasing trend to a substantial degree as FPG increased. A 1 mmol/l increase in FPG and 2h PG concentration was associated with a -22 and -21% decline in ISI(M), -16 and -4% in 1/HOMA-IR, -38 and -35% in DI(30) and -36 and -26% in DI(120). The decay constant of ISI(M) and DI(30) in IFG or ISI(M), 1/HOMA-IR, DI(30) and DI(120) in IGT was lower than that in normal glucose tolerance. Significant interactions between sex and glucose levels determining DI were found. CONCLUSIONS: We conclude that impairment of insulin sensitivity and insulin secretion contributes to both FPG or 2h PG hyperglycaemia in a Chinese population, but that the decline in insulin secretion is more pronounced with increasing fasting than 2h PG.
File Format	HTM / HTML
ISSN	14628902
Issue Number	2
Volume Number	14
e-ISSN	14631326
Journal	Diabetes, Obesity and Metabolism
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2012-02-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Metabolism Discipline Endocrinology Discipline Pharmacology Discipline Diabetology Asian Continental Ancestry Group Blood Glucose Metabolism Fasting Blood Hyperglycemia Insulin Resistance Insulin-secreting Cells Insulin Adult China Epidemiology Cross-sectional Studies Female Glucose Tolerance Test Humans Ethnology Secretion Male Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology

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