NDLI: Metformin directly inhibits ghrelin secretion through AMP-activated protein kinase in rat primary gastric cells.

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Metformin directly inhibits ghrelin secretion through AMP-activated protein kinase in rat primary gastric cells.

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Metformin directly inhibits ghrelin secretion through AMP-activated protein kinase in rat primary gastric cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gagnon, J. Sheppard, E. Anini, Y.
Description	Country affiliation: Canada Author Affiliation: Gagnon J ( Departments of Obstetrics & Gynecology and Physiology & Biophysics, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.)
Abstract	The antidiabetic drug Metformin causes weight loss in both diabetic and non-diabetic individuals. Metformin treatment is also associated with lower circulating levels of the orexigenic hormone ghrelin. To test whether Metformin directly affects ghrelin cells, rat primary stomach cells were treated with Metformin and the levels of ghrelin secretion, proghrelin gene expression and activation of adenosine monophosphate-activated protein kinase (AMPK) were examined. Metformin significantly reduced ghrelin secretion and proghrelin mRNA production and both these effects were blocked by co-incubation with the AMPK inhibitor compound C. Furthermore, the AMPK activator 5-amino-1-ß-D-ribofuranosyl-imidazole-4-carboxamide (AICAR) significantly inhibited ghrelin secretion. Additionally, ghrelin cells were shown to express AMPK. Finally, Metformin treatment caused a significant increase in the level of phosphorylated (active) AMPK. Our results show that Metformin directly inhibits stomach ghrelin production and secretion through AMPK. This reduction in ghrelin secretion may be one of the key components in Metformin's mechanism of weight loss.
File Format	HTM / HTML
ISSN	14628902
Issue Number	3
Volume Number	15
e-ISSN	14631326
Journal	Diabetes, Obesity and Metabolism
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2013-03-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Metabolism Discipline Endocrinology Discipline Pharmacology Discipline Diabetology Amp-activated Protein Kinases Metabolism Chief Cells, Gastric Drug Effects Ghrelin Metformin Pharmacology Animals Animals, Newborn Female Gene Expression Regulation Secretion Pregnancy Rats Rats, Sprague-dawley Signal Transduction Stomach Weight Loss Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology

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